Eight Supplements That *Actually* Work

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Here are the links to the research papers referenced in the video:

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#Health #Supplements

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[MrAntonioDP]

1. Creatine
2. Tmg
3. Psyllium Husk
4. Collagen Peptides/Hydrolized Collagen
5. Hyaluronic Acid
6. Multivitamins
7. NAC
8. Omega 3

[jwcas]

0:06: 💪 Creatine is an effective supplement for improving exercise performance and muscle recovery, with potential cognitive benefits and no significant adverse health risks.
0:06: Creatine monohydrate is the most effective nutritional supplement for increasing high intensity exercise capacity and lean body mass.
0:49: Creatine supplementation enhances measures of memory performance, especially in older adults.
1:20: Creatine poses no adverse health risks, including no link to kidney dysfunction or baldness.
2:06: TMG may improve muscle performance and building when combined with exercise.
2:50: 💊 Supplementing with TMG, Omega-3, psyllium husk, and collagen peptides may have potential protective effects for heart and brain health.
2:50: High blood levels of homocysteine are a potential risk factor for Alzheimer's disease or dementia, and TMG supplements may lower homocysteine levels.
3:19: Omega-3 supplements may reduce the risk of heart attacks, as shown in the VITAL trial and Mayo Clinic meta-analysis.
3:57: Psyllium husk, a source of fiber, can help reduce cholesterol levels.
4:19: Collagen peptides have been shown to benefit skin health, including reducing wrinkles, and may have additional benefits compared to protein alone.
5:59: 💊 Supplementing with hyaluronic acid and a low-dose multivitamin can have significant benefits for skin health and overall micronutrient intake.
5:59: Hyaluronic acid supplementation improves skin hydration and reduces wrinkles.
6:39: Hyaluronic acid does not accelerate cancer growth.
7:11: A low-dose multivitamin helps reach optimal daily intake of micronutrients.
7:45: The speaker designed a specific multivitamin called Micro Vitamin to meet these requirements.
8:15: 🔑 As we age, our levels of oxidants increase and glutathione levels decrease, but supplementing with glycine and NAC can help restore the balance between oxidants and antioxidants.
8:15: Oxidants increase and glutathione levels decrease as we age.
8:35: Glutathione is a powerful antioxidant that helps maintain the balance between oxidants and antioxidants.
8:42: Supplementing with glycine and NAC can help restore glutathione levels.
9:13: Knack has the least evidence among the discussed supplements.
Recap by Tammy AI

[kimdavis]

I’m 61 & on almost all of those mentioned…& I feel AMAZING!! 👍👍👍

[orioles]

I take most of the supplements that Brad talks about on this video. I use a combination of glycine and NAC but I don’t take a multivitamin. I take other vitamins instead like a multi B vitamin and D3 combination with magnesium and K2 and most of my supplements comes from do not age. Yesterday I visited my primary doctor and went over my blood test results and he gave me a once over and said for a man of 64 I am in excellent health. A 90% whole food diet, supplements and walking 5 miles a day is what is working for me. I am recovering from shoulder replacement surgery and plan on getting back to lifting weights as soon as I finish PT.

[phillipgriffiths]

Vitamin D and K2 should be included here!

[fooleos]

Appreciate the update on the supplements you personally take, excellent info!

[kekoakaawa]

Man, I wish I could take collagen peptides. Every time I do I feel anxious and depressed. I read an article somewhere, that says collagen powder lowers tryptophan, which lowers the amount of serotonin in your body-which can cause sleep disturbances, anxiety and depression. I also read that glycine- which collagen powder has a lot of, is a serotonin inhibitor. Some people seem to be negatively affected mentally/ emotionally by collagen peptide powder- sadly, I am one of those people. Not to mention- collagen powder can also generate oxalates and increase histamine- both of which I am also sensitive to. So not only do I get depressed and anxious on it, but I also get allergies and acne breakouts- ironic as it is supposed to benefit skin beauty.

As for hyaluronic acid- as far as I know hyaluronic acid is made through a process of fermentation or uses a fermented product-fermented products increase histamine in the body- and I am histamine sensitive. On hyaluronic acid supplements I experienced nasal allergies/ stuffy nose.

I wrote this for anyone who may be experiencing these symptoms on these supplements but don’t know why.

In an effort to benefit my skin and muscles instead of collagen peptide powder and hyaluronic acid supplements I have been focusing on increasing my quality protein intake- eggs, fish, beef, chicken- organic. As for hyaluronic acid- I have been focusing on produce like sweet potatoes.

Hope this helps.

[LTPottenger]

Taurine also boosts NAD+ levels, and reduces NADH in the cell, unlike nmn and niacin.

[richardmalone]

I have chronic bronchitis. As I get older it has been getting worse. I learned about how NAC relieves bronchitis by loosening the phlegm and make it easier to get rid of instead of coughing endlessly and not getting relief. I take 2 grams per day and it has been great. I can feel that I am getting full satisfying breaths and the need to clear the tubes is no longer constant. Just two or three times per day and it clears easily.

[andreipastushuk]

A proper chapters breakdown would surely make this video better!

[Phoenixpapagei]

I am a scientist too. From the initial studies I thought NAC was safe. In the doses given in the low and high ranges reported in some of the Aging research papers you have cited on this channel everything looks like rainbows. However, this is far from the full picture. NAC sequesters Zinc and Copper, up to dangerous levels. Moreover, NAC in some people (10% of the population) can lead to dangerous anaphylactoid reactions. I got an anaphylactoid reaction from NAC from just taking it 10 days !( I was checked before by a doctor and had no health concerns before this happened). Other people on the internet have self-reported brain fog, dizziness, and other problems derived from long-term intake of NAC. In other studies it has been found that NAC can promote inflamation in the HPA axis. It is true that ROS increases when we age, and NAC might have a theoretical benefit for some people. Regardless, we DO need to perform more research on what causes the side effects seen in all anaphylactoid reactions so we can prevent them.

[dfooau]

The only issue with creatine is it triggers my elderly mother's gout and certainly the kidneys (she has borderline poor kidney function). So, unfortunately I stopped giving her creatine for her mental improvement. The throbbing painful toe in the morning after a dose of creatine is not a subjective experience when you can see it and feel it.

[funkykong]

Thank you for your recommendations and research!

[trompetsopp]

Brad, I had some completely unexpected, but highly positive effects taking a high dose vitamin b-complex recently. From my reading these vitamins are essential to mitochondrial function and neurological health. Yet they are seldom mentioned in longevity circles. Why? And why are they not in your supplement stack?

[antonystringfellow]

The 2022 GlyNAC study used doses of 1.2 g each of NAC and Glycine, 2.4 g of each and 3.6 g of each.
The results showed a significant increase in Glutathione only in those with high oxidative stress and only after pooling together the results from the 2.4 g and 3.6 g per day groups. This seems to suggest that no benefit is gained in those not suffering from high oxidative stress and even then, a minimum dose of 2.4 g per day of both Glycine and NAC (4.8 g) is required.
Another study (Kumar) used a much higher dose still and found no benefit in taking NAC without a similarly large dose of Glycine. That study used a dose that for me would amount to 7 g of NAC and 15 g Glycine per day.
Considering the above, I see no point in anyone taking 1 g of NAC per day, with or without Glycine.
Btw... I ordered some NAC before reading the papers in full.
Note to self: Don't buy anything based on an abstract or conclusion you've read - read the whole goddam paper first! lol!

[arthurdolle]

I have read that NAC should be taken with an equal amount of vitamin c. In recent talks about in NAC I haven't seen a mention of that. Do you think that's valuable?

[lofm]

From decades of personal experience: DMAE works awesome to improve concentration. Saw Palmetto extract works great to shrink the prostate.

[comradecatbug]

Alternatively, you could just have a healthy and balanced diet and get all the nutrients you need from your food. Especially vitamins and fiber. It's been shown that vitamin supplements aren't utilized by the body as effectively as vitamins from whole foods.

[jgesselberty]

Used creatine regularly and had three bouts of kidney stones. Stopped use and have had no stone for 15 years.

[MissesWitch]

What I really love about you is how you always make updates about these sorts of things!

As new studies and research is always coming out!

Recommendations always change, Some things are removed and some things are added, So it's always nice to know!