The connection between sleep and Alzheimer’s disease | Peter Attia, M.D. & Matt Walker, Ph.D.

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About:

The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 40 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.

[ConsiderItHealth]

This was so good to be reminded of. I love hearing Dr. Walker talk about sleep. He is just awesome with giving very relatable analogies.

[judokoning]

Hi guys,
I recently did a literature review on this topic. I found that the amount of deep sleep in humans is decline during aging up until the age of 60 where there is almost no deep sleep at all. I also found why this is happening. I would like to come in contact to debate this. We could change the world of Alzheimer together.

[pubwvj]

A question for Dr. Walker: have you looked at the same flushing question for patients coming out of anesthesia?

I love anesthesia. It is so increasingly refreshing. I have had six anesthesias in my life and every time I wake feeling far more refreshed than a night’s sleep. The waking is slower, in peaks and troughs over about an hour. I have had two sleep studies which showed my sleep is fine, other than unusually large amount of REM stage.

I wonder if anesthesia has the same effect you describe but possibly more so.

[garyyencich]

So if these undesirable proteins, amyloid and tau, are being flushed out of the brain during deep sleep where are they being flushed to and how does the body eliminate them?

[charlesoneill]

How much deep sleep should you get? I do not sleep well. I frequently get less than 35 minutes and never more than 1hr and 15 minutes.

[pabloblanco]

Excellent topic and lecture. You don't need to be concerned about what the doubters think because I know for a fact that what you have stated is in fact true and credible. My grandfather had sleep disruption for decades. He would doze off and wake up every hour or two and he developed Alzheimer's around 70 and passed away from Alzheimer's complications (hypernatremia) at age 80.

[bradh]

"Perhaps the default state of life on the planet was sleep". "And the LORD God caused a deep sleep to fall upon Adam, and he slept: and he took one of his ribs, and closed up the flesh instead thereof; And the rib, which the LORD God had taken from man, made he a woman, and brought her unto the man." Genesis 2:21-22

[weckuptothis]

How can you measure if you are getting the right amount of the type of sleep needed to prevent? Fitbit says I’m getting about 1.5 hours of deep sleep a night …