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Treatment of acute gout

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Contraindications to NSAIDs?
Acute or CKD; CHF; peptic ulcer dz; anticoagulation
If not → NSAIDs (indomethacin)
Contraindications to colchicine?
Severe renal or liver disease
Combined with another drug inhibiting cytochrome P450 system
If not → oral colchicine
If contraindications to both, consider oral, IV, IM, or intraarticular glucocorticoids
If two or more joints involved, consider oral, IV, or IM glucocorticoids
Contraindications to NSAIDs?
Acute or CKD; CHF; peptic ulcer dz; anticoagulation
If not → NSAIDs (indomethacin)
Contraindications to colchicine?
Severe renal or liver disease
Combined with another drug inhibiting cytochrome P450 system
If not → oral colchicine
If contraindications to both, consider oral, IV, IM, or intraarticular glucocorticoids
If two or more joints involved, consider oral, IV, or IM glucocorticoids
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