Keto Diet Mistakes: High Protein Levels May Kick You Out of Ketosis- Thomas Delauer

Keto Diet Mistakes: High Protein Levels May Kick You Out of Ketosis- Thomas Delauer… The reason too much protein is bad for ketosis is because our bodies have a fundamental energy process called gluconeogenesis - translates to “the making of (genesis) new (neo) sugar (gluco.)” During gluconeogenesis, the liver (and occasionally the kidneys) turns non-sugar compounds like amino acids (the building blocks of protein), lactate, and glycerol into sugar that the body uses a fuel. When glycogen is low, protein intake is high, or the body is under stress, amino acids from your meals and your muscle become one of your main energy sources.

Gluconeogenesis and Your Liver:
As mentioned, the process of gluconeogenesis takes place primarily in the liver, where glucose is made from amino acids (protein), glycerol (the backbone of triglycerides, the primary fat storage molecule), and glucose metabolism intermediaries like lactate and pyruvate. Lactate is produced by a breakdown of muscle tissue and sent to the liver through the bloodstream - at night, when we haven't eaten for several hours, the body begins to manufacture glucose using gluconeogenesis.

Study:
A study published in the American Journal of Clinical Nutrition looked at the effects of gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet.
Wanted to see whether a high-protein, carbohydrate-free diet (H diet) increases gluconeogenesis and whether this can explain the increase in EE (energy expenditure.)
10 healthy men received a high protein, low carb diet (30%, 0%, and 70% of energy from protein, carbohydrate, and fat, respectively) or a normal-protein diet (12%, 55%, and 33% of energy from protein, carb, and fat, respectively) for 1.5 days.
Endogenous glucose production (EGP) was lower in the high protein, low carb group than in the normal protein, higher carb group.
However, researchers found that there was a 42% of the increase in energy expenditure after the high protein, low carb diet, explained by the increase in gluconeogenesis - the cost of gluconeogenesis was 33% of the energy content of the produced glucose.
Concluded: With the high protein, low carb diet, the contribution of increased gluconeogenesis to increased energy expenditure (EE) was 42%. Although, other energy-requiring pathways in protein metabolism, such as protein synthesis, may contribute to the increase in EE after a high-protein diet, the results of the study showed that gluconeogenesis contributes to a major part (42%) of the increased EE.

References:

[isaacsanchez]

Down 98 lbs on keto and intermittent fasting thanks to you Thomas, and good old Dr. Berg!

[bidnow]

Ketosis starts when liver glycogen is diminished, not muscle glycogen.

Ketosis and keto-adaptation is best analyzed as a 24 hour cycle, and perhaps not so much around a single or few meals and protein "spikes."

[piyushdimri]

@Thomas: this is the biggest mistake to drop the protein on ketogenic diet. Chasing Ketone levels in low carb doesn’t really benefit specially in fat loss. From evolutionary stand point too we don’t need to be in ketosis all the time.Moreover GNG is a demand driven process and it’s hard way for body to get glucose for brain, which we really want not the exogenous form.
I would say higher amounts of fat would be detrimental to fat loss goal because body uses exogenous fat not the stored body fat.
Extra exogenous fat is gonna be deposited into the adipose tissues which are already being overfilled and are hypertrophic due to insulin resistance. Body specially in IR state cannot produce new subcutaneous fat cells to store lipids. Hence lipids spilled over into visceral or ectopic fat.
Ted Naiman, Ivor Cummins, Gabor Erdosi have very interesting findings.

[kevinorges]

Great video. A month ago my ketones dropped significantly and I couldn't find out why...to much protein.

[tiffinycheek]

thanks for this. I fount this very helpful. It answered some questions i had about protein, and if i was getting to much or not enough. Thanks Thomas. look forward to seeing little Thomas and to see how big he has gotten .

[peterfaber]

This is true. I was eating way too much protein in the beginning and ended up with fasting glucose levels of over 100 mg/dl. Once I realized I was eating too much protein, I reduced it to the right level and it took about 3 days to get fasting glucose down to around 85 mg/dl.

[Alelevier]

Awesome vid and info as always!! Thanks!!!! I don't measure my ketones but I've felt a bit off when I have a big meal with more protein than fat, I've been a skeptic of gluconeogenesis but I've felt the effects on my body, now I'm 100% sure as of why, thanks again

[ranklin]

Always learning something new on this channel thanks so much man!

[roberthanratty]

Great way to explain how proteins get converted to sugars, via in ketosis state.

[crownofthorns]

Super important video! The hardest part of keto for me is cutting down protein, maybe because I'm stressed very frequently. Sometimes I wonder if I'm fully fat adapted because I'll break my fast with bulletproof coffee (treat it like a meal and won't eat for another few hours) and then still have low blood sugar-like symptoms before I eat a meal even if I'm not quite physically hungry yet.

[God-is-Great]

Not entirely true. Glycerol is the main substrate for gluconeogenesis not amino acids. Besides The amino acids for gluconeogenesis does not come from muscle breakdown but from other sources. Proteolysis (muscle breakdown) happens in starvation not ketosis

[countryfriedketo]

Thank you. You answered a question I've had for a while in this video.

I've been doing keto for a little over 9 months straight without really coming out of ketosis (haven't had a desire to cheat or eat anything non-keto).

I've lost a ton of weight, have gotten ripped with abs -- a lifetime goal of mine -- and feel better than I ever have.

I measure my ketones frequently using a blood meter (like 3-4 times a day usually), and I've heard Dr. Dom and others talk about post-exercise ketosis.

But I've been confused because my ketones usually drop down to about .5 - .7 post workout, but after a ton of water, some fats (including quest mct powder), they always go back to 1.4 - 2.5 or so.

I thought I may be doing something wrong.

But thanks to you I realize those folks meant non-keto people who exercise enough to deplete liver glycogen can experience post-exercise ketosis. Is that correct?

[msannethrpe]

Thank you for this info and putting it so plainly and to the point. With so much conflicting info out there, I appreciate your scientific approach backed up with studies.

Great info and eloquently explained. Thank you

[whatthefingA]

It matters to know the science you teach. Thank you so much, Thomas! Very informational n.n!

[LightningStrikes]

Great video, love the honesty of the channel, the VHS definitely gives up your age bro, I remember those days

[meesho.]

Thanks for the insight Thomas!! I appreciate all your videos! Do u have a keto calculator app??? I think I trust your calculations vs. Others lol

[TheJessejr]

Thomas, I just heard about the explosions in Austin and I think you’re there right now. Praying you and your family are ok. Please let us know when you can

[miyahayashi]

I’m just jumping into a ketogenic diet to deal with hormonal/insulin issues. I really appreciate all of the physiological breakdowns you do in your videos! I’m having a hard time discerning what vegetables, oils, meats etc. that I can lean on during this season of my life because of the inconsistencies from person to person. I trust your knowledge and was wondering if you could please point me towards a list of foods I can make meals from! Thank you!

[AM-uimc]

I asked this many times. What about YERBA MATE and fasting? I drink 1-1, 5 liters a day while fasting. This is extracted from 25-30 grams of yerba mate