Can Intestinal Infections Affect Bile Composition?

#intestinalinfection #bile #gut

Intestinal infections can change the composition of liver bile, leading to changes in immune function and gut bacteria, potentially helping fight off harmful bacteria.
Researchers have identified a new axis of host defense by studying what happens during enteric infection -- a term that encompasses all types of intestinal infections including so called "stomach flu." A new study from infectious disease investigators at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, uncovers how bile, a solution produced by the liver and responsible for the absorption of fat, plays a role in the fight against infections. Results are published in Nature Microbiology.
"The changes we detected in the composition of bile with infection are beneficial for the intestine to clear infection," said Matthew Waldor, MD, PhD, of the Brigham's Division of Infectious Diseases.
"Our findings reveal the intricate and dynamic nature of bile composition, shedding new light on the liver's critical role in defending the intestine from infection. These insights enhance our understanding of the liver's broader functions in regulating physiological stability and metabolic processes."
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