Sepsis: Everything You Need to Know

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Chapters

0:00 Introduction
0:45 Symptoms of Sepsis
2:10 Causes of Sepsis
3:02 Diagnosis of Sepsis
3:24 Treatment of Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.[4] This initial stage is followed by suppression of the immune system.[8] Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.[1] There may also be symptoms related to a specific infection, such as a cough with pneumonia, or painful urination with a kidney infection.[2] The very young, old, and people with a weakened immune system may have no symptoms of a specific infection, and the body temperature may be low or normal instead of having a fever.[2] Severe sepsis causes poor organ function or blood flow.[9] The presence of low blood pressure, high blood lactate, or low urine output may suggest poor blood flow.[9] Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement.[9]

Sepsis is caused by many organisms including bacteria, viruses and fungi.[10] Common locations for the primary infection include the lungs, brain, urinary tract, skin, and abdominal organs.[2] Risk factors include being very young or old, a weakened immune system from conditions such as cancer or diabetes, major trauma, and burns.[1] Previously, a sepsis diagnosis required the presence of at least two systemic inflammatory response syndrome (SIRS) criteria in the setting of presumed infection.[2] In 2016, a shortened sequential organ failure assessment score (SOFA score), known as the quick SOFA score (qSOFA), replaced the SIRS system of diagnosis.[4] qSOFA criteria for sepsis include at least two of the following three: increased breathing rate, change in the level of consciousness, and low blood pressure.[4] Sepsis guidelines recommend obtaining blood cultures before starting antibiotics; however, the diagnosis does not require the blood to be infected.[2] Medical imaging is helpful when looking for the possible location of the infection.[9] Other potential causes of similar signs and symptoms include anaphylaxis, adrenal insufficiency, low blood volume, heart failure, and pulmonary embolism.[2]

Sepsis requires immediate treatment with intravenous fluids and antimicrobials.[1][5] Ongoing care often continues in an intensive care unit.[1] If an adequate trial of fluid replacement is not enough to maintain blood pressure, then the use of medications that raise blood pressure becomes necessary.[1] Mechanical ventilation and dialysis may be needed to support the function of the lungs and kidneys, respectively.[1] A central venous catheter and an arterial catheter may be placed for access to the bloodstream and to guide treatment.[9] Other helpful measurements include cardiac output and superior vena cava oxygen saturation.[9] People with sepsis need preventive measures for deep vein thrombosis, stress ulcers, and pressure ulcers unless other conditions prevent such interventions.[9] Some people might benefit from tight control of blood sugar levels with insulin.[9] The use of corticosteroids is controversial, with some reviews finding benefit,[11][12] and others not.[13]

Disease severity partly determines the outcome.[6] The risk of death from sepsis is as high as 30%, while for severe sepsis it is as high as 50%, and septic shock 80%.[6] Sepsis affected about 49 million people in 2017, with 11 million deaths (1 in 5 deaths worldwide).[14] In the developed world, approximately 0.2 to 3 people per 1000 are affected by sepsis yearly, resulting in about a million cases per year in the United States.[6][7] Rates of disease have been increasing.[9] Sepsis is more common among males than females.[2] However, other data show a greater prevalence of the disease among women.[15] Descriptions of sepsis date back to the time of Hippocrates.[16] The terms "septicemia" and "blood poisoning" have been used in various ways and are no longer recommended.[16][17]

[JohnnySparklez-oyro]

I was just diagnosed with Sepsis. I'm homeless with two beautiful dogs. Got a hold of my father and he's going to take me back to the ER .thanks for posting this. Pray that I make it home with my dogs ..

[mnm-dsjb]

I was just diagnosed with sepsis and diverticulitis. I’ve been in the hospital 5 days now, feeling much better. The doctor has me on several antibiotics not sure when I’m leaving. Thanking God I got to the ER when I did, I thought I had a flu bug didn’t realize body was shutting down

[roseviera]

I got sever sepsis thank God I'm alive thanks to God and Dr's and nurses in icu God bless them ❤❤❤❤❤❤

[chrystallee]

Recently had Sepsis. A simple UTI to kidney infection and Sepsis. Was caught early by ER Doc. My lactate level was 7.1 so glad it was caught early!

[BradGilroy]

My Mom has frontotemporal dementia and developed a fistula yesterday. The surgeon didn't recommend surgery and it seems likely she will succumb to sepsis eventually when she stops responding to medication. She turned 60 a week ago...I was told dying of sepsis was the next best thing to dying in her sleep. What a jagged little pill life has given this beautiful woman. 🥺

Thank you for this video. At least now I know what we are about to experience.

[DevinWillSurvive]

Ohhh, so sepsis is a state and not the infection itself. Thanks for the informations!

[andrewstrohecker]

I recently had sepsis this past week. Thank God the hospital caught it when it did

[petergroverd]

Went to visit my Brother in hospital a couple of days ago with this horrible condition. Thanks for the info ...It helps to understand.

[GeorgeGlass]

My Father who was in remission from cancer in the blood stream woke up with a stomach pain and went to the hospital. 12 hours later he was dead. He was only 75. They were doing tests all day but he was getting worse and disoriented. No clue why they didn't start running antibiotics in him right away. I was at work and had my work phone, nobody knew the number. When I got home, my personal phone was full of messages to get to the hospital. I walked in to see the Doctor do one less pound with his closed fists on his chest and that was it. My Dad's stomach was bloated, he had blood coming out of his mouth and his eyes were open. I had to close them. I was in shock. This happened a year and a half ago, and I still can't sleep. Why didn't they realize what was up after a few hours? I have fallen into a depression and need to get help. I'm 57 and divorced, no kids, and my life is falling apart. Please pray.

[xXxHallwaysOfHecatexXx]

I've had this. Was diagnosed with Sepsis and salmonella never been so ill in my life. Was off school for a month and in hospital for most of it.

[shaunmurphy]

I got blue lighted to hospital on a Thursday. Turned out i had double pneumonia with sepsis. Docs and nurses get ten out of ten. Discharged on tuesday and on the bank fishing on the wednesday

[kattsplosion]

Ibsurvived septic shock and haven’t been the same since. I lost everything and am really struggling. Sometimes i just wishes and prayed it took me then. Because no one tell you about the struggle afterwards.

[keyboardbunny]

Stress, poor diet and poor lifestyle leads to immune system going all crazy. I think everyone is focusing what medications and surgery procedures can be done to patch disease and not looking at how to just prevent the root cause of it all.

[donmcvay]

My mother and brother both died from sepsis caused by hospital born infections. Hospitals are very danderous places

[jcsondrei]

My wife been sick for 2 weeks now due to this illness. The symptoms are fever, chills, dizziness and feeling weak. Her doctor said the anti biotics ivy killed the bacteria thru her blood but somehow she still been sick as of now. Still getting chills and fever and dizziness. Plan C is they might put a small camera inside her lungs to check if theres bacteria hiding in those areas. 😢

[Yo-yo-dtze]

I had this a couple months ago due to a uti infection the only symptom I had was not able to urinate at all if I hadn’t walked into the er I would have never know I had sepsis and would have been dead iam a sepsis survivor

[astronautnestar]

What is the permanent cure for severe sepsis?

[linjoy]

there was no mention of Sepsis following birth of a baby. I had what used to be called Peurperal fever, it was the infection that until the advent of antibiotics caused the deaths of mothers who had just delivered their babies. Childbed fever is another name for this awful infection. I had just delivered my son I was 19 years old and married a year, I was in so much pain until the antibiotics worked. I was lucky that the antibiotics used had only been invented 5+ years before, otherwise I'd have died.

[_Ptat_]

Just a random photo of crucifixion 😂😂😂 I mean yeah, I guess you’d get sepsis eventually from the nails, but you’d die from dehydration long before you got sepsis

[PlanetarySponge]

I was in the final stage septic shock and almost doed