Ketogenic Diet makes Mitochondria LESS EFFICIENT - Effect on Fat Loss? [Study 21]

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Created with Biorender

0:00 - Introduction
1:05 - Ketones on Fat Cells
2:09 - Ketogenic Diet Mitochondria Effect in Living Creatures?
3:00 - Ketogenic Diet Mitochondria Effect in People?
3:47 - Understanding the Science
5:22 - White Fat turning to Brown Fat
6:02 - Conclusions/Take Aways

Created with Biorender.

#brownfat #keto #ketogenicdiet

[McCarthy]

If fasting prevents the body from burning fat for energy that would defeat the entire evolutionary purpose of fat. I don't care what some controlled study in a lab showed. I've lost 50 pounds in 2 months by fasting 5 days a week and eating high high calories 2 days a week after an intense full-body workout at the end of the 5 day fast. And I barely lost any muscle too.

[jennym]

Do I want to mega boost my metabolism? What are the advantages other than burning calories? What are the disadvantages? Shorter life span? Increased aging? Decreased energy? Increased brain aging? More wrinkles? More fatigue? Please discuss.

[pedrogouveia]

this makes a lot o evolutionary sense, given that this is exactly what you would want if you where a hunter gatherer or farmer, during the spring or summer you would have access to higher carb foods which would allow you to be more metabolically efficient and also more active, during winter, as you change your diet to more animal based sources and enter into a fat based metabolism, your body starts producing more heat due to the mitochondrial inefficiency, allowing you to stay warmer during winter.

[wilmerwalton]

I appreciate all the work you're doing on our behalf, explaining the science of metabolism, and the latest relevant research. It wasn't that long ago that saying you're overweight because of a metabolism problem sounded foolish. After being a vegetarian for 25 years, I couldn't give myself permission to switch to keto, until I was convinced by recent science, I needed to change my metabolism. To a degree, the question of "how" has been answered. You've created a low impedance path, and keep me on it, to understand the "why."

[CheyenneChild-]

Hey Nic! With the fat loss being sort of spot-specific, do you think this has any implications in storing/burning of visceral fat vs subcutaneous in humans? For example, it's fairly well known, I believe, that fructose metabolizes mostly in the liver, and stores in the liver much like ethanol does: viscerally. Perhaps ketogenic diets for whatever reason incentivize burning visceral and storing subcutaneous?

[omi]

Does having more ketones equal to more mitochondria uncoupling? Or is there diminishing returns after a certain point?

[Bepartofthepanacea]

Appreciate for ur great work, do we store toxin and heavy metal in out fat storage processing? That later if we try to burn them we actually going to release toxin and bunch of unhealthy components?

[MauricioCrespo-xo]

I have myalgic encephalomyelitis, my english is not good so I didn’t get what to do

[PerryScanlon]

Is this why exogenous ketones don't seem to benefit athletes?

[MarmaladeINFP]

There are other effects, including improved mitochondrial functioning and cellular health. Ketones are the preferred energy source of the brain and heart, where mitochondria are concentrated. They also reduce inflammation, reverse unneeded or unhelpful epigenetic changes, and offer a cleaner fuel. Fat-burning more generally, whether or not in ketosis, is able to skip some steps in the electron transport chain in order to, as I recall, create less ROS.

In this process involving the mitochondria, besides being efficient in producing ATP, ketones produce far more metabolic water than carbohydrates. Metabolic water is deuterium-free, which is combined with fatty acids being low-deuterieum (as long as they're not industrially processed; e.g., seed oils). Excess deuterium causes problems in numerous ways, particularly slowing down mitochondria. This is why a keto diet, fasting, exogenous ketones, etc have such broad benefits.

[janelhartman]

under perfect conditions, how long does it take for mitochondria to replicate?

[wheelofcheese]

As usual, I’ll just have to take your word for it (despite you talking clearly and plenty of pictures). I must have some type of fetish where I like to feel stupid lol.

[littlevoice_]

Do ketones improve mitochondrial function in the brain hence the reported improvements in cognition?

[epickiller]

There's a piece missing, thyroid function. Thyroid function will go down on a keto diet and will reduce ATP production. This will slow down everything and overtime will lower caloric expenditure, this is probably a back up mechanism to counter act lower ATP production.

[okritsky]

It is not less efficient))) It is more profitable, because it's less lactic acid -> less carbon dioxide -> less breathing during exersising -> less acidation of muscles -> longer working. why do we need "efficient" way if after 40 secs of work there's a lot of lactic acid and no longer possible to continue with all over breathing (huffing and puffing) because of excess of CO2 in blood as a consecuence of getting lactic acid in the blood. Oxigen consumption by cells leads to local hypoxia which leads to local NO2 generating which initiates building of additional local blood vessels to the cell, providing better metabolism after a month there. the cell becomes tireless. There's always enough oxygen during exersising. We struggle only because there's too much CO2 in the blood (only from your "efficient" way of making ATP - glycolisis instead of my "less efficient" oxidative phosphorilating).

[blastfilmmaking]

If we dont need to lose fat... does that means (mitochondria deficiency) that we will have less energy? Which is the best way to feel more energised?

[lauftrainer_falk]

Thank you for this video. Am I correct in saying that mitochondria prefer fatty acids for fuel and ketones are a signal (UCP) for uncoupling when ketosis occurs? So the mitochondria protect themselves from free radicals and the excess fuel created by the ketone diet is released as energy in the form of heat.
My experience is that the oxidative capacity is generally increased. I noticed this in my endurance runs, as I can now run the same distance with a lower heart rate.

[raymilland]

No only does a ketogenic diet help the mitochondria it also can help starve cancer cells and reduce inflammation and a bunch of other good things.

[womanhikerone]

The mitochondria takes more food/substrates on a keto diet... higher metabolism. So the mitochondria is less efficient on a keto diet... although this is a good thing because more calories are burning.

Other info say that keto is more efficient in making ATP energy because it requires less oxygen to make ATP.

This bio-chemistry language gets tricky, I've noticed.

[elhombreloco]

Hey Nic! Is the reason why total ATP production stays the same because beiged fat have overall higher number but less efficient mitochondria?

What's the effect on ROS production? I would assume less efficiency means more ROS? But if the ROS production is distributed among more mitochondria it might still be manageable? Does this potentially mean that very long term keto might not be a good idea? Is ROS balanced out by autophagy that's pretty commonly induced in ketogenic diets?

What's your thoughts?