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Regeneration of Diseased Kidney
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Led by scientists at Duke-NUS Medical School and the National Heart Centre Singapore, researchers in Singapore and Germany have found that renal tubular cells, which line the tiny tubes inside kidneys, release a scar-regulating protein called interleukin-11 (IL-11) in response to kidney damage. This leads to increased expression of a gene that arrests cellular growth and promotes kidney dysfunction. In a preclinical model of human diabetic kidney disease, the scientists showed that turning off this process by administering an antibody that binds to IL-11 led to proliferation of the kidney tubule cells and reversal of fibrosis and inflammation, enabling damaged kidney cells to regenerate and restoring impaired kidney function.
#research #kidney #regeneration
#research #kidney #regeneration
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