The Shocking Truth About Ozempic & The Effects It Has On The Body | Calley Means & Tyna Moore

Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails.

Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between.

In this episode, we discuss:
The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34)
Challenging the notion of treating obesity with drugs like Ozempic (10:35)
An unsettling revelation about the push for using Ozempic in children (12:04)
Digging deeper into GLP-1 research and some of the benefits (32:51)
Why are children being born metabolically challenged? (41:11)
Dr. Moore’s approach to using peptides with her patients and for her own crippling pain, and what they’ve seen (45:19)
How our current healthcare system lacks policies and support for behavior change (1:27)

While there are always differing views, we know for sure that our food and drug policies aren’t serving the best interests of creating sustainable, empowered health for the masses. I hope you’ll tune in to hear more from this comprehensive and lively discussion.

This episode is brought to you by Rupa Health, Pendulum, ARMRA Colostrum, and One Skin.

[williamhenry]

I am 75 years old and went for my first blood test of my life. My last physical was in 1969. The doctor asked if I smoked. That's it. Didn't ask what I ate, how I slept or if I exercise. I told her I fast and she said "Why would you fast?". No paperwork for the blood test. Just a call saying my cholesterol and LDL are a bit high. It was a joke. Guess I'll wait another 55 years for my next physical.

[RJweblink]

I will be forever thankful to my parents who deprived me and our household of soda growing up.

[albertvargasUX]

I was on Ozempic for 3 years. Went from 230 to 180lbs. My A1C went from 11.0 to 4.8. My fasting glucose reading was at 300. Now its 89. I have not been on Ozempic for a year now. I have not gained any weight and my sugar is still at 4.8/89. Ozempic taught me how to eat again but it def killed my cravings. That has been the hardest part of being off of Oz. You don't have to be on it for the rest of your life but you do have to change your life if you want to change perm

[philosophizeyourlife]

Tyna Moore is clearly making the most logical argument here. I wish she were my doctor!!

[maisie]

I’m 73 years old — I was in severe constant pain; I couldn’t move my head nor bend. Over 8 years ago diagnosed with chronic severe degenerative arthritis— told “nothing to be done” I Got cervical fusions with titanium etc also lumbar fusions too. I had 2 small strokes & much more that I won’t get into. Decided to change my life - went from keto- eventually to carnivore. I’m so well. The plethora of meds - now in the bin. I no longer take any meds. I walk miles daily. I’m at the best optimal weight ever — and ever so well -- and have been for over 5 years.

[marabolin]

As a school lunch lady I know first hand how poorly we nourish kids at school.
Having to follow the government food guidelines, which require grains, vegetables, fruits, meat, milk. Believe me, the meat is minimal and usually contains sauces and gravies, which stretch the amount and add sugar and seed oils. The fruit is canned also containing sugar. The breads, which we do make fresh each day, yet made with shortening, sugar and flour. Breads also often times are bread sticks covered with margarine and spices. Vegetables are canned ( often sweetened) or frozen to which is added margarine and salt.
Then there’s dessert which we usually make from scratch, but again more shortening, sugar and if it has fruit it’s sweetened.
Beverages served are milk, white and chocolate ( and of course most children choose chocolate MORE sugar) and fruit juices ( MORE SUGAR). The meals are extremely high in carbohydrates! Extremely high in sugar! It fills their belly’s with basically no good nutritional value at all!! It breaks my heart

[Avoid_Low_Frequency]

Registered Nurse here. This topic is so interesting and the time has come for Americans to advocate for their health. If you wait for the Medical community to catch the train, you’re late already!

[straightupcurlssherrycasse]

I started this 4 weeks ago. I have Hashimoto’s. I have normal blood pressure, A1-C, and cholesterol. I eat mostly Whole Foods. I never felt hungry. I started this and I feel like a different human. I have bone on bone knees and a bad hip. All need to be replaced. My first shot was on Saturday night at 8:30. I peed all night. Woke up and could take my rings off. I had lost 5 lbs of water/inflammation, all my pain is gone. I finally feel hunger which allows me to know when I’m not hungry. I feel 20 years younger, I’m 62, and my foggy brain is gone and my depression is gone. It has truly been a miracle! I feel hope! I’m also only taking .25 and I don’t plan to go up! I am 5’8” and 289.4. I have not weighed myself yet, but I know I have lost weight.

[rulesfortheenotforme]

My mom is using Monjouro and she has lost 120 pounds. She needed a leg up to get a kick start on this journey… she felt helpless for decades… she is keto now also.. but these drugs are not a solution if there is no lifestyle change…

[fleur]

WHY IS NOBODY ASKING THIS QUESTION: If Ozempic slows gastric emptying to such an extent that food is sometimes still in the stomach days later, is it even physically POSSIBLE for a patient to digest the required amount of protein in a day to avoid muscle loss? Everyone keeps saying Ozempic is safe so long as you exercise and eat enough protein, without asking if their bodies can even digest that amount of protein while on the drug.

[mythals]

I can see it from each of their perspectives. Tyna is talking very specifically about set circumstances where the conditions are tailored to the patient. Hyman is open more to the idea of it being natural within the body and likely offering some benefits but knowing the limitations are important. Calley is looking at this from a pharma/food insider and understanding their motives, he is concerned about the longer term affects on the average patient, knowing most don't have doctors like Tyna and Hyman who will take the time to tailor solutions. They all have valid points.

[michaelhalstead]

Im not pro GLP1 but Calley’s approach is like telling alcoholics and addicts to quit drinking and doing drugs.

[katiedingman]

As a non-average American, with mold toxicity, autoimmune, hormone imbalance, POTS, etc., I really appreciate Dr. Tyna and Dr. Hyman sharing their knowledge! I need help getting back to homeostasis, and it’s been SO hard. This gives me hope, which I also need. I agree with the young man that America’s food system and pharmaceutical system is corrupt, but as someone who isn’t able to exercise (used to be three sport athlete & trained for a half marathon) I need help getting back there. Thanks for this podcast! Great listen!

[littleguynoir]

Some people need to understand that addiction is often stronger than the will to live. Junk food is addictive, that is pretty well accepted. Getting off of junk food can be like getting off of heroin. Thank you Dr Hyman for understanding that there are so many sides to so many issues.

[krissynh]

You know what people who have never been obese miss? They miss it every. Single. Time. It's not about eating less and moving more. It's about the food noise experienced by people with obesity. They also miss the chronic feeling of hunger and the inability to feel satiated. I just started taking Wegovy and overnight that all stopped. My self-control, my motivation, my drive did not change. I am the same person. I just don't wake up thinking about food. I don't feel constant hunger. I don't feel the need to keep eating after I know I've eaten enough. If I never lost another pound I would keep using Wegovy to just have the peace in my own mind. All of the sudden I am enjoying healthier eating and exercising. All of the sudden I am able to "eat less and move more" without feeling deprived. This is a turning point in obesity treatment. I agree that our food environment is toxic. If 30% of the population suddenly were eating smaller portions and eating healthier it would change our whole economy and ultimately our food environment. I am team semaglutide for sure. It may not work for everyone but it will change obesity treatment, and how we understand obesity and that is a very good thing.

[mtadje]

Thank you Tyna for your expertise. I’ve had a normal BMI my entire life. Hit my 40s and went through menopause early, and I have hashimotos. I’ve always exercised and ate healthy my whole life. I started gaining weight, had no energy, body was always hurting, depression. Tried everything…..no sugar, no gluten, keto, carnivore with no results. My dr prescribed the lowest dose 2.5mg of Zepbound (tirzeptide). It has changed my life. I lost the 30lbs I had gained over the last 4 years. Have more energy, healed my gut, no more hot flashes. We are now lowering my thyroid medication. I take a 1 week off each month. Loved hearing Tynas perspective. Wish they would have let her talk more.

[bifsavage]

When one person is saying “it’s not all good or all bad” and the other guy says “semaglutides are the devil”, I’m going with the rational thinking.

[mariecasey]

Dr. Tyna Moore's information is great. Her take on GLP1 was new for me and was presented in a clear and concise manner. Her skill as a practitioner who is able to think out of the box and advocate for her clients was on full display and 
refreshing.

[christinepadua]

It’s always refreshing to see intellectuals come together to discuss nuance information and still respect each other. The problem I have with Calley’s stance is that what happens when you are a Vegetarian (like myself) who uses food as medicine and exercises 7 days a week (I’m a Ballerina, runner, and Yin Yoga practitioner), yet, my hereditary high cholesterol doesn’t go away; therefore, rendering me as a lifelong recipient of my statin drug. Sometimes, people really have a genetic mutation, like I do, whereby my HDL is not operating properly since I was a kid. Therefore, statins were the solution, even though I worry that it is damaging my liver. What else can I do? As for Tyna and Mark, thank you for your knowledge. I will ALWAYS be your fan and virtual patient. I truly and highly respect you guys.

[stay_cee]

I appreciate the docs bringing up those of us that are doing the things - and still don’t lose fat. I eat the protein, prioritize fiber, eat
Probiotic foods - and a supplement, prioritize sleep, resistance training with progressive overload, do functional fitness exercises, some cardio but nothing excessive, minimal processed foods, work to actively reduce stress, and I honestly have great labs (not insulin resistant ) and I am building muscle., .. but it’s nearly impossible for me to lose fat (confirmed with DEXA scan ). I have to cut calories severely and when I do I no longer have the energy to do the exercise. Some of us just don’t have a simple answer.
I’m an educated person that has always cared about what I put in and on my body. Yet it remains extremely difficult for me. Yes most people aren’t putting in that kind of effort but I like the idea of micro dosing the med to help me deal with the hunger and reduced energy that comes from calorie restriction. And unless you have worked as hard as I have and lost zero fat - you might not understand