HISTAMINE INTOLERANCE: Symptoms, Root Causes in the Gut Microbiome, and Treatment

Learn all about Histamine Intolerance, which can cause a wide range of symptoms throughout your body. Learn the mechanism of histamine buildup in the body, and all about the DAO enzyme made in the gut microbiome, which normally breaks down histamines. What foods can cause symptoms in Histamine Intolerance? Learn why DAO levels can be impacted by an unhealthy gut microbiome in SIBO, Dysbiosis, or Leaky Gut. Learn about the gold standard of diagnosing Histamine Intolerance. In this video, Dr. Rajsree Nambudripad, MD reviews how to manage symptoms with a low-histamine diet and supplements that are cofactors for the DAO enzyme. She explains how healing the gut is the key to restoring your DAO enzyme and treating Histamine Intolerance.

Dr. Rajsree Nambudripad, MD is board-certified in Internal Medicine and founder of OC Integrative Medicine in Fullerton, CA.

00:00 Introduction
01:50 Symptoms of Histamine Intolerance
03:39 Allergies vs. Histamine Intolerance
05:28 Breakdown of Histamine by DAO
06:19 Production of Histamines by Histidine Decarboxylase
06:30 Foods High in Histamines
09:07 3 Sources of Histamines
09:28 Root Cause of Histamine Intolerance
10:04 SIBO
11:24 Dysbiosis
12:23 Leaky Gut
13:22 IBS
15:00 How to Diagnose Histamine Intolerance
15:29 Low Histamine Diet
18:21 Testing and Healing the Gut
19:44 Anti-Histamines
21:01 Digestive Enzymes
21:39 DAO Cofactors
22:06 Probiotics
23:26 Avoid DAO Blockers
23:53 Histamines in Women
24:32 Histamines and the Menstrual Cycle
25:13 Histamines in Pregnancy
25:49 Mast Cell Activation Syndrome
27:17 Systemic Mastocytosis
27:56 Case Example
29:31 Key Points

➡️Watch Dr. Rajsree's video on SIBO:

➡️ Watch Dr. Rajsree's video on Candida and SIFO:

➡️ Watch Dr. Rajsree's video on Leaky Gut:

➡️ Watch Dr. Rajsree's video on Mast Cell Activation Syndrome (MCAS):

✅ Review Article on Histamine Intolerance with Table of DAO Blocking Medications:

🧡 Shop for Supplements by Dr. Rajsree:

⭐Learn more about her practice here:

💙 Facebook:

💚 Instagram:

💌 Sign up for Dr. Rajsree's weekly newsletter:

📦Dr Rajsree's Amazon Favorites:

This information, including but not limited to, text, graphics, images and other material contained on this video and website are for informational and educational purposes only. No material in this video is intended to be a substitute for professional medical advice, diagnosis, treatment, or medical supplement approved by the Food and Drug Administration. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Never disregard professional medical advice or delay in seeking it because of something you have seen in this video. No physician-patient relationship is created by this video or the information provided. Furthermore, neither Rajsree Nambudripad, MD or any contributor to this video, makes any representations, express or implied, with respect to the information provided herein or to its use.

[drrajsree]

Thanks for watching everyone! Please post your questions and comments below ⬇. I look forward to hearing from you! To shop for any of the supplements described in the video, please see link below:

[welshlady]

This video contained more clarity and information on my symptoms than I got after spending tens of thousands of dollars and countless hours with naturopaths.

[gutmicrobiomequeen]

🙋RE: Dysbiosis and SIBO: There was a paper recently that showed *Klebsiella aerogenes* is the biggest histamine-producing bacteria in the gut microbiome. Also- WOW! This is one of the most comprehensive videos on histamine intolerance on Youtube! Rock on, doc!

[Ruktiet]

Thank you SO much for this video. I had to figure all of this out by myself. When I explained what’s wrong with me, why my life was falling apart, no one around me would believe that these conditions even exist, let alone that I have them.

Having you as a medical doctor explain all of this is a godsend for me to convince my parents and friends of what I’m struggling with and will eventually probably lead to them helping me more and being more understanding.

Invaluable channel, truly!!!

[earthmamma]

This was so amazing. I’ve been having digestive problems and itchy skin for years. No one has ever mentioned histamines. I’m bringing this to my doctors attention.

[DanielleLegacy]

This woman has a gift. She explains things so clearly. I've learned so much just from watching only 2 of her videos. Things I couldn't get clear answers on for months, if not years. I wish I could find a competent doctor like her near me. 😩

[gilliancarter]

What a clear and excellent video! I have been suffering terribly with every symptom you describe (and more!) for 4 years now. I have been dismissed by doctors and specialists alike. It was not until I found good information on Youtube that I started to improve. No words can describe the suffering of this condition in some- with the relentless insomnia adding to the misery with constant exhaustion. Thank You so much!!!

[poasei]

Over 10 years of many symptomes especialy anxiety and heart palpetations and many digestive problems as bloating and diarhea I suspected this for many years but my doctor didn't go along with my story.I've even taken anti depresants and saw many doctors who said it was in my head.I will do my very best to heal my gut as the last 10 years have been full of anxiety attacks, having to use the toilet on the most inconveniant moments, sweaty palms, the list goes on.this has to stop because I can't enjoy life 100% like this.thanks for the great video.greetings from belgium.

[swanwynonUT]

Thank you so much Doctor for the life saving education.
My diggestive issues are indigestion, bloating and constipation.
I have watched your remarkable videos about microbiome issues.
I was on cimetidine for 20 years.I don't take it any more.
I avoid trigger foods, fish, gluten, dairy products, grains, sugar
, fruit juices. I eat romaine lettuce, carrot, zucchini, cabbage,
chickpea, hemp seed, organic peanut butter and chicken bone broth.
I take digestive enzymes, zinc, magnesium and
methyl B complex. So far it works wonderfully.

[BGPsychology]

Thanks to your videos after 11 years I finally found the source of my problem and research for a doctor in my country who understand this problem SIBO and HISTAMINE INTOLERANCE. Thank you good doctor and have a happy holidays!

[joannebuttner]

This gives me hope in overcoming long covid 🙏 I would love to work with a doctor like this who actually aims to address the root cause of the illness as opposed to using prescription drugs to mask the symptoms

[giselleaberdeen]

I'm just thrilled to have found this video as I have been struggling for quite a while with hives and histamine issues without much help. Docs don't seem to want to investigate further and I'm developing more and more issues with my gut especially and even genitourinary area, much to my distress. Would be so great to talk to someone who actually is knowledgeable about these issues and cares to see patients get better. I'm stuck doing all this self-diagnosis and research and really just don't know where to turn. Am tired of being in pain after eating, though it seems to occur randomly and have not been able to isolate what hurts me. Was told I could have something called mastocytosis years ago but they have just had me on daily bilastine for this... if I miss even one day, I get the hives on my lips and hands - miserable life. I'll keep watching more of your videos and see if I can discern which of your products might be best for me but any help would be appreciated. Does anyone from this channel take any sort of consults via e-mail maybe? Just desperate for help, it has been an absolutely miserable time... I'm worried even to try the quercetin or things to help rebuild microbiome as I seem to react with pain in the kidneys to almost anything. Very strange and discouraging. Sorry for the long read; just glad to have found all of this information. God Bless.

[Angel_Dinev]

Thanks, Doc! You are a lifesaver providing these valuable insights and guidelines for improving our overall health! One day MD education will be done in such clear and understandable way as is in your video lessons. Keep the great work! 🙏

[BBWBARBIE]

I watched this and cried you don’t understand thank you so much for taking your time to make this video…..I got long covid that processed to one stroke 7 TIAs and a severe food sensitivity on top of a autoimmune disease and no doctors have helped one but this video has done more for me in 30 mins then doctors have done for me in 3 years

[sharvari]

For anyone suspecting histamine tolerance for themselves, I highly suggest you get an allergy test because your body may not react to histamine released from certain items that may otherwise be high in histamine. For example, I do not react to citrus fruits and milk but respond to potatoes that are considerably lower in histamine. See what works for you so that you are not limiting your options!

[queenb]

This video was by far, the best detailed review of cause, symptoms and plan of action to restore gut health and reverse histamine intolerance. Stress, post C19 infection plus bronchitis lead to 3 rounds of antibiotics over the past 1.5 year. This altered my healthy gut and set me on a 6 month down slide of stomach issues, sleep disruption, eczema explodion, feet and hands blistered and itching skin that is hideous, anxiety. I'm grateful you have given a road map to recovery. I'm ordering these supplements to get this underway immediately. Wish me luck. Thank you Dr. Nambudripad!!

[teenag]

To echo many others, thank you for this! I have dealt with many of this issues for 20+ and my 19 year old son deals with many of them. I've been suspecting we have histamine intolerance and supplementing with digestive enzymes and DAO, as well as L-glutamine, vitamin D, quercetin, and b vitamins. My father and I have started watching your videos to work on potentially healing leaky gut. We face the problem of not being able to find any actual doctors that understand food issues, and functional medicine practitioners not being as knowledgeable as we would hope. I have 2 questions: 1. Do you know of any doctors with training similar to yours in Texas that we could see to interpret tests or do you consult virtually with patients? 2. Is there any harm with supplementing with berberine, oregano oils, and allicidin prior to testing?

[pilarkrol]

This is by far the best video on Histamine intolerance 👏🏼🙏🏼♥️

[janicetr]

Thank you so very much for this video! People look at me like I'm crazy when I tell them about my stomach and bowel issues. I don't have a colon and only have a small intestine, so I believe that's why I suffer so much! I contracted c-diff in the hospital when I had a routine hysterectomy many years ago. It turned into toxic megacolon, and I had to have my whole large colon removed to save my life. That was in 2021 and my life had never been the same. I wish you were my physician. I will try some of your products. Thank you so very much!!!

[gretaosborne]

This was VERY informative. I started looking deeper into what triggers these allergies. I remember hearing something about histamine not long ago and it came across something else I was watching. I thought I had it pinned down, but started to see other things that seemed to be triggers. I thought it was just seasonal allergies, but after watching this video and a few others, I noticed I ate a lot of those foods that are high in histamine. Thanks for sharing your knowledge. I'm jumping on this!!