Debunking Cholesterol Myths: New Study Reveals Surprising Findings! With Dave Feldman

Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

*Produced by Mountain Valley Media

00:00:00 Podcast begins
00:03:30 The genesis of Dave’s most recent study
00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic
00:22:30 Dave’s overall perspective while conducting studies
0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis
00:42:30 How the medical community has received this study
00:46:30 Do credentials matter?
00:58:30 Thoughts on Statins
01:04:45 What alters lipid levels
01:13:30 Connect with Dave

References:
Twitter: @realdavefeldman
Instagram: @realdavefeldman

[joerizzo]

I am an LMHR. My LDL is 315, HDL 87, Triglycerides 53. I am 63 years old and have been eating Carnivore, Keto for over 3 years. I lift weights 6x per week and don't do cardio exercise. I have a zero carotid artery calcium score., and a fasting insulin level of 4.3, and bodyfat of 12%. I love how I look and feel and want to thank Dr. Saladino, Dave, Feldman, Dr. Baker, Dr. Berg, Dr. Ekberg, Dr. Berry and many others for the great content that showed me the way.

[damescholar]

65-year-old female here. LDL 310, HDL 221, triglyserids 50. My Apo-B is very good. Doctors have been formerly fretting about my high LDL, but my heart and lungs and veins are in an excellent condition for my age. I am a fairly healthy eater now but I have had eating disorders when I was young. I exercise moderately (walking, hiking, weights, swimming, climbing), and have never smoked.

[bcjammer]

I’m 36 and very fit/active and been fairly strict carnivore for 5 year. Literally feel like the guy from limitless. Not an exaggeration. Doc tried to prescribe me a statin because my LDL is 372, HDL 57 and triglycerides 100. Nonetheless I refuse to believe that a way of eating that makes me feel so good can be bad for me.

[ElizabethMillerTX]

I'm LMHR (nearly identical demo/#s as the study cohort averages), and on this (moderately low-carb, primarily animal-based) diet to help manage a hereditary connective tissue disease and the alphabet soup that comes with it (hEDS, POTS, MCAS, thyroid, seizures, etc). This work is HIGHLY relevant to me and many others like me. Might as well study me, because I'm not giving it up diet gains, or taking a statin, without a really, really good reason. Thanks to Dave, and everyone else who makes this work a reality. Thanks, Doc, for continuing to educate on cholesterol. I'm so very, very grateful.

[RandomHuTaoSimp]

Incredible. It's only a matter of time until the real info takes over and the truth becomes mainstream

[dougprosser]

Peter where you at? Sit down with Dave and have an open discussion and go over this study. If you believe in the process of science and fancy yourself as an open minded thinker, step up.

[Sjj]

My LDL is 276, HDL is 86, Triglycerides 46. I have a very clean diet, no processed food. I exercise. My doctor called me today and told me to take the statin thats waiting for me at the pharmacy. Its frustrating cause I live a healthy life and now Im being told i have familial hypercholsterolemia. I never tested for that. My doctor is just going by my high LDL cholesterol. I also did an NMR test and the LDL size is 206 (normal). Also Im female age 40.

[davidzip]

There was no correlation between baseline plaque because everyone with elevated plaque was excluded from the LMHR cohort. Dave knows this and willfully hides it.

[star-warsien]

Note for people, these results are for people that have a LDL-C >= 200mg/dl AND HDL-C >= 80 mg/dl AND TG <= 70 mg/dl. Paul S. doesn't even meet this criteria given his blood work back in March 2023: LDL-C -> 207 mg/dl, HDL-C -> 56 mg/dl and Tri -> 108 mg/dl. Not that its bad but just a note that this study applies to this particular LMHR phenotype. Paul mentions that if you are insulin sensitive and have High LDL/HDL and low Tri then you should be good the data only trends with that logic, doesn't encapsulate it fully. Paul needs an AB study, just like this one.

[hexturbo]

Keep up the good work guys. Absolutely ground breaking stuff here!

[Straycurrent]

Thanks, gentlemen, for another enlightening conversation. These are exciting times. I'm enthusiastic about further developments.

[susanbeever]

An interesting point regarding macrophages and plaque: about 50% of them are not true macrophages because they are dedifferentiated vascular smooth muscle cells (VSMC) after TRPV4 on VSMC causes them to dedifferentiate to macrophage-like smooth muscle cells. The same applies to osteoblast-like VSMC that calcify the artery.
TRPV4 is on monocytes, macrophages and VSMC.
TRPV4 is an osmotic and mechanical sensor and is up-regulated/stimulated by hypertension, hypoosmolality, pharmaceuticals and more. Over stimulation of TRPV1 causes hypoosmolality by stimulation of the pituitary to secrete ADH and is a natriuretic at the kidney.
Excessive stimulation of TRPV1 causes excess ROS and leads to lipid peroxidation that the true and macrophage -like VSMC phagocytize.
The low carb ketogenic diet decreases sugar that decreases TRPV1.
The principles of TRP functionality are key to understanding the LMHR by keeping glucose low and you see the opposite with high glucose/TRPV1 in polycystic ovarian and metabolic syndrome. The PCOS is because up-regulation of TRPV1 on primary cilia breaks its stabilization of tubulin in micritubules that deactivates polycystin 2 (TRPP1) the same TRP receptor responsible for primary renal cystic disease.
TRPV4 on monocytes leads to M1 inflammatory macrophages, increased mcp-1 and lp(a) that attaches to apoB.

[LifeDIY]

Thanks for the update! I believe I fit into this category of LMHR too. But, one thing no one is talking about it, is if these people are experiencing any issues with the state that they're in. I have a terrible insomnia problem that I never had prior to carnivore (never had in my lifetime - I have narcolepsy) and I feel like I am having some blood sugar issues and other imbalances (which may be part of the cause of my sleep problems). I'm working on incorporating things to trigger insulin and fix this. I am curious if any others are experiencing problems because this is really impacting my life.

[JMK-vopv]

Hey Paul and Dave, the next time some dogmatic lipidologist or angry lawyer tries to belittle you for a lack of credentials, how about bringing up the fact that many trained and licensed physicians used to recommend cigarette smoking as part of a healthy lifestyle or advised pregnant women to ingest thalidomide for nausea or insomnia!

[cttofr]

About 5 years ago I wanted to participate in this study as a lmhr. Study was at capacity for participants. I debated family members and evangelized the idea the high ldl was a red herring. Vindicating to see this incredible data. Careful that my bias is obvious, but the idea the ldl is causal is also a bias towards garbage in garbage out data analysis we may have witnessed in medicine. Thanks Dave and Paul for doing science a favor, and progressing knowledge, starting a conversation and leading the charge

[AKMcF]

Fantastic to see you covering this, good man, great podcast !

[firelight-vitality]

How long was the follow-up in this study? There is no link to the study in the description.

[madeleinegrayson]

Why are people going to docs and taking tests?? Genuinely curious.

[rsolom]

Question: I am 65, not lean but have a bmi of about 28. Been working out my whole life, 5’7, 185. Normal cholesterol levels : hdl-72, trig -80, ldl-190, apob 130., bp 120-80. Diet: since June mainly carnivore lost 20 lbs to now 185. Any thoughts???? Thanks

[iked]

LDL 148, HDL 44, cholesterol 211 and triglycerides 96. My CAC 152. I don't know if I have FH?? I am 47 year male who excises regularly and my diet is up and down. My doctor wants to put me on a Statin because of my numbers. They also tell me not to eat more then 6 eggs/week and stay away from red meat. I have not taken the statin because I don't like the side effects and risk of diabetes. Do i just lower my carbs and stick with a carnivore diet?