METHYLENE BLUE: Impacts Longevity By Boosting Mitochondrial Efficiency [2024]

My long-awaited video on Methylene Blue covers just about everything I know about this compound. Methylene Blue’s primary claim-to-fame lies in it’s ability to boost ATP production and increase mitochondrial efficiency.

In today’s video, we’ll talk about what Methylene Blue is and it’s history. Then we’ll dive into how it works, with an introduction to cellular respiration. Finally, we’ll go into it’s impact on the aging process, how to take Methylene Blue and some considerations when supplementing with this molecule.
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Chapters & Timestamps:
Intro: 00:00
What Is METHYLENE BLUE? : 01:12
Laying The Groundwork: 02:36
Free Radicals: 07:09
METHYLENE BLUE: 09:24
METHYLENE BLUE's Also Neuroprotective: 12:21
METHYLENE BLUE Inhibits Skin Aging: 14:26
How To Take METHYLENE BLUE: 14:54
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Studies Refered To In This Video:
The Potentials of methylene blue as an anti-aging drug:

Multimodal randomized functional MR imaging of the effects of MB in the human brain

Ultraviolet radiation protection potentials of metheylene blue for human skin and coral reef heath:

Anti-aging potential of methylene blue for human skin longevity:

Hemoglobin, methylene blue and oxygen ingteraction in human red cells:

[praxix]

The best explanation I've seen with the clearest graphics. Well done!

[lomotil]

🎯 Key Takeaways for quick navigation:

00:29 📜 *Methylene blue is a compound that shows significant potential in impacting aging and longevity.*
01:19 🔄 *Methylene blue, historically used as a dye and medication, has a long safety record and is on the World Health Organization's List of Essential Medicines.*
02:19 ⚡ *Methylene blue acts as an "electron cycler, " similar to NAD, shuffling electrons to enhance cellular respiration and ATP production in mitochondria.*
03:39 🔗 *Cellular respiration involves Glycolysis, the KREBS Cycle, and Oxidative Phosphorylation, with the Electron Transport Chain (ETC) playing a crucial role.*
05:59 🌐 *Methylene blue's presence in mitochondria increases ATP production efficiency by enhancing the function of complex 4 in the ETC.*
07:23 ⚠️ *Free radicals, formed during cellular respiration, contribute to intrinsic aging; antioxidants like methylene blue counteract this damage.*
09:16 🧠 *Methylene blue's neuroprotective and nootropic capabilities include enhancing brain cell respiration, improving memory, and increasing attention.*
11:54 🩸 *Methylene blue improves oxygen-carrying capacity in red blood cells, explaining its use in treating carbon monoxide poisoning.*
12:50 💡 *Methylene blue's hydrophilic and lipophilic nature allows it to penetrate biomembranes, including the blood-brain barrier, enhancing its neuroprotective effects.*
13:38 😌 *Beyond cognition, methylene blue has anti-depressant effects, inhibits skin aging, and can promote wound healing.*
15:55 💊 *Methylene blue is recommended in a 1% solution form, with dosages varying based on body weight, and precautions against serotonin syndrome should be considered.*
18:50 ✅ *Methylene blue offers a range of benefits, including boosting energy levels, enhancing cellular function, and potentially addressing mitochondrial dysfunction, making it a compound worth considering for anti-aging supplementation.*

Made with HARPA AI

[marinavolosov]

I’ve been taking 4 drops twice a day, 5 days on, 2 days off. I don’t have any health issues, but I noticed more energy throughout the day, my attention doesn’t jump from one thing to another, irritation disappeared, digestion improved, easier to make decisions, easier to stay focused, more relaxed overall. I’ll keep taking it… forever! Thank you for the video, I loved the infographics and your very clear explanation!

[davidbogdan]

Best explanation I have seen you checked all the boxes while not going too far in the weeds, really gave everything we needed. 1? can always go and do a dive into the research if needed.
It’s been a game changer for me and my fatigue.

[md]

Here are the key points about methylene blue summarized in bullet points:

- Methylene blue is a compound with a long history of use as a dye and medication
- It has various beneficial properties:
- Neuroprotective - improves cognition, memory, and mood
- Antioxidant - scavenges free radicals and improves mitochondrial function
- Enhances oxygen delivery by improving hemoglobin function
- Anti-aging effects on skin by protecting against UV damage
- Mechanism of action:
- Acts as an electron cycler, similar to NAD, improving ATP production in mitochondria
- Bypasses earlier complexes in the electron transport chain to enhance complex IV activity
- Dosing guidelines:
- Use pharmaceutical-grade, avoid industrial or aquarium grades
- Typical dose is 45-360 mg per day, split into 2-3 doses
- Avoid high doses (>10 mg/kg) which can become pro-oxidant
- Potential interaction with serotonin-enhancing medications or supplements

[LuckyBeechdub]

Excellent video. I recently began using MB. I do not have any health issues but I can tell you that I feel absolutely AMAZING using it. 🔥

[bonniedavis]

Best Methylene Blue video ever!!! Understandable, very throughal. excellent job! subscribed

[ShimmeringWind]

This contained more information than the so-called pros. I've listened to . Thank you so much for doing such good research.

[MarcMallary]

You learned it good and explained the process better than some doctors.
I've been mixing it with vitamin C, that turns it more clear. I heard it explained that it makes it work better. I use the powdered with a tiny spoon.

[l_pops]

Best schematic explanation I've seen yet on the electron transport chain (ETC)... great work Lance. I'm saving this video for future reference.

[johnolaoluwa]

Lance's explanation is the best I've ever seen on the molecule. I discovered a methylene blue supplement, Mitotaur, it's brilliant for me, I seem to have bundles of energy since using it, it's like an internal air conditioner. 😊

[whorn]

Have seen some warnings about it raising blood pressure, but I take same dosage of BP med that I've been taking and haven't noticed any difference in pressure since starting on MB a week ago. I love it.

[lectrix]

Ive been doing research into methylene blue for some time. This is one of the most succinct and clear videos on the topic I've come across to date. Great work!

[christopherdavis]

I had a UTI for about a month, wouldn't go on its own. I refuse to take anti bi's unless absolutely necessary. Discovered MB, 20 drops in 4 oz of water. UTI gone in about 4 days, never returned. I take MB regularly now just for regular health benefits Inc as a nootropic 👍

[worldchampofxrp]

My nonverbal autistic 7 yo son did a Mitoswab test and his Complex 4 was very low (22% of normal mean). His RCII+III was also very low. I am starting him on Methylene Blue (10-20 drops) mixed in tea so he can sip it. Your video is the first I have found talking about the electron chain and specifically complex 4. I hope this helps with is mitocondrial improvement. Have you heard of successes for autism with Methylene Blue? Thanks!

[RAYGXEN]

For 100 kg (approx 200 lbs) the 1% concentrated solution, the most viable dosage is 4 ml per day (you can take 2ml in the morning, 2 ml in the afternoon, but none in the evening, because it can interfere with your sleep) the energy boost lasts about 5-6 hours which is miraculous.

[BeauBody]

Best video on MB I’ve seen. The infographic is a work of art - for the first time I think I understand what’s happening at the cellular level. So glad I subscribe to your channel.

I wonder if you take it daily or cycle?

[TC-mfcq]

The dosage recommendations are for IV use for serious illnesses/poisonings, not for taking orally. Keep that in mind when you're taking it and start with a low dose.

[cocis]

Thank you so much for all the effort it must have taken to produce this video. It's excellent. I think it'd only be improved by making references to the research papers that support MB's properties so we know how much evidence there is and what quality that evidence is.

[ryanastoner]

Dude, great freaking work on this video.