Vitamin B12 (Cobalamin) Deficiency - Causes, Symptoms, Diagnosis & Management - Hematology Series

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RDW is elevated in Vitamin B12 deficiency as well as in folate deficiency.
Strict vegans are at risk of developing vitamin B12 deficiency.
To make red blood cells during hematopoiesis, DNA replications require the presence of vitamin B12 and folate.

Folate is stored in your liver for months.
Vitamin B12 is stored in your liver for years.

Vitamin B12 (cobalamin) deficiency = Megaloblastic anemia+ Neurological Symptoms.
Folate deficiency = megaloblastic anemia [withOUT neurological symptoms]

(Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.)

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[TPEsprit]

Just saying, I am a committed vegan and obtain B12 from cereals. Keeping well after circa 10 years. Animal products also have their drawbacks, especially red, processed meats and dairy, best avoided. Good video, thanks and best wishes. 🕊️🧡✨

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I watch all ad on your vedio, ,
i didn't watch it because I am busy but feel that content is perfect, ,

[nervusvagus]

Vitamin B12 stored in the liver for YEAAAARS

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[Thornlessrose]

Most informative so thank you for taking the time of explaining this in great detail. My Hematologist has written a report to my doctor noting that I have developed mild Pancytopenia and have already started on B12 injections last month. My B12 is within normal range however the HoloTC (Holotranscobalamin)level was abnormal so is still being looked into as to why. I have been having severe Hemiplegic Migraine with other Neurological conditions over the past 3 years.

[DaniloGebrin]

This B12 is a promiscuous vitamin. First it binds to R protein, then to intrisic factor and in the end to the transcobalamin

[ali]

thank you for the explanation. you forgot to add tests for pernicious anemia including anti-intrinsic factor Ab and anti-parietal cells Ab.

[drmaqsoodali]

Excellent explanation of pathogenesis and diagnosis of Vitamin B12

[meggbaker]

I came to this video in the hopes that it would help me understand my B12 deficiency after seeing a neurologist for my symptoms. It was very helpful in understanding the processes; however, I just wish the doctors could tell me the REASON for my deficiency. I’ve been receiving injections but I’d still like to know why.

[abdulazizabbara]

Yayyy our genius has a video about my presentation title 💃

[susanyoung]

Thank you! SO complex. PS: some chronic parasitic infections eat our RBCs and B-12. Over several years time they cause Malabsorption, chronic fatigue, B-12 anemia. Hookworm, Babesia, and Fish Tapeworm. Case numbers exploding. Doctors do not know about this!!! And the lab tests for them are often false-negative. 😖🤬 Thanks for helping us.

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[michaelconnors]

American Academy of Neurology:

People with inflammatory bowel disease may also be at risk for
developing nerve damage and other neurological problems, according to
research that will be presented at the American Academy of Neurology’s
59th Annual Meeting in Boston, April 28 – May 5, 2007.

Inflammatory bowel disease includes digestive disorders such as
ulcerative colitis and Crohn’s disease that cause swelling and/or
bleeding in the intestines. For the study, researchers compared 103
people with Crohn’s disease and ulcerative colitis to 51 people with
other digestive disorders, such as irritable bowel syndrome, gastritis
and chronic heartburn.

The researchers found that those with inflammatory bowel disease were
about four times more likely to develop neuromuscular conditions,
including carpal tunnel syndrome and small fiber neuropathy, which
causes pain and lack of feeling in the feet. Those with bowel disease
were also more than six times more likely to also have a disorder called
sensorimotor polyneuropathy, a nerve disease that can cause weakness,
pain, and numbness. These diseases were more common in women with bowel
disease than men.

“Inflammatory bowel disease patients commonly suffer from several other
medical conditions, like B12 deficiency and glucose intolerance. These
nerve conditions we have reported are often not diagnosed by their
primary care physicians, ” said lead study author Francisco De Assis
Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in
Ceará, Brazil, and a member of the American Academy of Neurology.
“People with inflammatory bowel disease who develop new symptoms, such
as pain or numbness in the feet, should see a doctor.”

[faisalbadsha]

Greetings of the day Sir, you are doing a great job. Your lectures are very impressive, precise, understandable & providing great concepts. Sir I want to ask you does Gastric sleeve surgery can cause Vitamin B12 deficiency. Thanks