Vitamin B12 Digestion and Absorption

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[armandohasudungan]

🧠 TEST YOUR KNOWLEDGE FROM THIS LECTURE! ✅

[jackiez]

We have been screaming to be heard for my daughter's MS related symptoms, and your video explains so much that we can now take to our deficient doctors. Thank you to taking a very complex issue and explaining in a way that we could learn it. Amazing!!!

[rollinstn]

DUDE, SERIOUSLY, your videos are the best. Thank you for all the great work, If I could subscribe more than once, I'd do it. You just saved me pages and pages of studyin in a 9 minute long and clear video. Thank you.

[mandeepbedi]

Excellent presentation...crisp ..clear...a visual treat and much more than textbooks...simply amazing
appreciate the skills...

[baleees]

YOU ARE AMAZING! I'm such a visual person and all of this... what you're doing... Everything just stays in my brain after one time of watching! No Kidding! THANKS!

[xDomglmao]

Comment from a different video, copy-pasted:

"I'd like to add something about the weird terminology here, just details but might help someone:
1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ("R" stands for "rapid electrophoretic mobility").

2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless".

3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 1:200k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs).

4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12").

5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use."

If you want to add/ correct something, feel free to do so

[miladsh]

You're a great artist and also a great teacher. thank you so much for all of your works.

[nickush]

Superb presentation, just what I was looking for. Clear, concise, great graphical support to your commentary... Very many thanks.

[youlisted]

Hello “Armando Hasudungan”.

You have been added on YouListed under the categories :
1) Sciences : Medicine and Biology
2) Sciences : Chemistry

[Shamsanus]

Thank u so much !! Iam really waiting for ur book .. Good luck !

[garystanton]

Another great video. One major cause of B12 deficiency which I was surprised you didn't mention is alcoholism. I will assume this is due to alcohol damaging the illium and preventing adequate absorption. Additionally alcoholism generally goes hand in hand with poor diet/malnutrition which also accounts for the deficiency.

[farisalshboul]

excellent step by step illustration as always, thanks very much Armando

[anhenovember]

Armando, you are amazing ! It is so easy to understand all those topics you tackle through your excellent drawings and explanations. Also you have a nice humble way about you. I hope you get into teaching as doctor! Your students will thank you!

[ayeshahameed]

Thank you so much . everything you explained was crystal clear and you explained in such a way that my mind was able to retain it just by seeing your video once.
Best of luck for future and stay bless

[gzlee]

loves all our videos. it's really helpful in understanding and all our drawings are really good. keep it up the good work

[yvettemorris]

Thanks Armando.. you are amazing!
Can you please think about posting a video of absorption, function and deficiency of vitamin B1

[cowesmoooovers]

This is the best interpretation of cobalamin absorption I’ve seen.

[michaelgershon]

U know what....I give you golden buzzer

[User-tonb]

i appreciate you so much that words cannot express

[payalas]

Wow this was very helpful and wonderful drawings! Thank you so much