Overview of DNA Repair Mechanisms

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.[1] Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs).[2][3] This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis.

Direct reversal

Single-strand damage

Double Strand Damage

SOS In Prokaryotes

[AVSMusic]

As a native English speaker I understood you perfectly. Don't listen to negative comments that try to insult you.

[aimanalikhan]

Your videos are really helpful in studying boring make the topic interesting and easy to learn....keep it up . God bless you

[alpha]

When you are watching an educational video, if your mind concentrates on the subject only, someone's accent wouldn't be much of a bother like some people are saying here. I, on the other hand, completely get engrossed by the way this man teaches.

[Maru-hrdg]

Waryah zyade asel. Proud of you. Great sir.🎉

[chandrlekha]

Thanks for easy explanation.❤️btw from which state u r ?

[sujinithish]

Very clear and proper also time saving class.😊

[ericwuluglayjr]

Also, please make videos on TOPOISOMERASE I & II, thanks teacher ❤🇨🇳💪🇱🇷

[Alert]

Ur every vedio is very helpful for me 🤗🤗, thankyou so much sir 🙏🙏

[tibayounis]

How can the dna polymerase know the mistake in newly formed strand and correct it??

[ericwuluglayjr]

All of your videos are perfect, keep uploading please

[JaspreetKaur-ewpo]

Hi. Can you please tell me clearly about 3rd one Double strand repair. It's confused. Actually I couldn't understand your voice right there.pls help me with those lines

[shibzz]

Where is detailed explanation of mismatch and nucleotide excision repair....??
Can u plz reply fast...

[AmishaMaithani]

Sir plz make a video on methyl directed mismatch repair

[rosyaryaseries]

please make vedio on splicing and other botany topics

[habibaansari]

Thanks alot...your all videos are fabulous l can get these videos very clearly....😁😁😁👍👍👍keep aploading such kind of nice videos sir...

[dinkysindhi]

plz make video on translation of eukaryotes plz

[abeer]

I did not understand because of your accent, plz try to improve your pronunciation brother 💗

[rajamalladisekhar]

your English accent is not understandable