Base excision repair

Base excision repair is a DNA repair mechanism that removes the chemically modified bases from the DNA. The Enzyme involved in Base excision repair is DNA glycosylases. The DNA glycosylases, enzyme removes the modified base to create an AP site. This site is then cleaved by AP endonuclease and repaired by DNA pol I and ligase.

[haileyyoung]

you've made a seemingly complicated process very easy to understand, thank you!

[FMshorts]

It's wonderful bro....now I, m feeling that it, s so easy to understand it

[mohamedelafia]

i think N Glycolase does not remove the base it just identifies the wrong base. ap endonuclease cleaves the region and the base will be removed from 5 exonuclease than comes polyemrase one with the base and finally dna ligase to repair the cleavage.

[blueballoon]

the animation shows a 3' to 5' DNA pol. but the narration say it was a 5' to 3' DNA pol, so which one is it?

[cameroonian]

Now that I see it, I understand. Thank you !!

[husammatar]

Thank you so much you are really goog to explain.

[wolfbaron]

What does AP Lyase do in this context?

[anowartheplantbreeder..]

When DNA glycosylases remove modified base then already 3'OH nd 5'P site open so AP endoculease what actually did??🤔🤔