DNA Replication (Updated)

Explore the steps of DNA replication, the enzymes involved, and the difference between the leading and lagging strand! This video is an update from our old DNA replication video with nearly the same script but added detail and improved art! See table of contents by expanding details.

Table of Contents:
00:00 Intro
0:11 Why do you need DNA replication?
0:27 Where and when?
1:12 Introducing key player enzymes
2:48 Initial steps of DNA Replication
4:04 Explaining 5' to 3' and 3' to 5'
5:09 Showing leading and lagging strands in DNA replication

Factual Reference:

***Further Reading Suggestions***

Our Resources:

Connect with us!

TIPS FOR VIEWING EDU YOUTUBE VIDEOS:

MUSIC:
Our intro music designed and performed by Jeremiah Cheshire.

COMMUNITY:
We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube's community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.

TRANSLATIONS:
Hindi Subtitles Credit: Alisha Aggarwal

[warwick]

Me in Middle School- Laughing at these videos.

Me in High School - Appreciating these videos for saving my life to prepare for exams.

Me in College: Literally thanking these videos for saving my entire degree.

[ashleygrey]

The fact you made a 11 minute video to explain what my teacher explained in 2 hours....

[davet]

Me, 82 year-old, high school grad, fascinated, self-educated, life-long learner...loving you for your amazing work.

[ameedalzndani]

As a medical student, I love this woman, always saving my life with these amazing videos. THANK YOU

[dunebuggy]

learned more from this than from my teacher with a PhD

[kennethng]

That moment when realize you're already in gradschool and still watching this to prepare for exams

[xDjiki]

I wish I’d watched this before I got a C on my biology exam… which I today gotta correct to an A. The fact you were able to explain this whole process in 8 minutes and my teacher couldn’t in literal HOURS of lessons is just amazing. Props to you!

[amsd]

I just love how the audience is growing up with the videos, a few years ago we were all doing either IB or AP and now we're coming back to this in college. Thank you for raising us amoebas! :D

[alnimri]

I remember my 9th-grade biology class using these videos to teach us. Currently reviewing for a DNA test in a college Microbiology class. Still just as useful as ever!

[vish]

This really helped me with the whole lagging strand thing.

[alleycat]

Right now, I’m a 9th grader studying for an honors bio unit exam, but I have a feeling I’ll be coming back to these videos in college! Your videos are always super helpful, especially for me since I’m a visual learner and struggle to understand concepts without pictures and graphics. Please keep doing what you’re doing!

Update: I got a 98 on my exam! Thanks so much Amoeba Sisters!

[Selenanina]

It's the way that I'm finished with my first semester of uni and my professor never explained why and how DNA polymerase only goes in a 5 prime to 3 prime direction. I learned an entire semester of biology in this one video and I'm beyond grateful or else I would have failed my exams. ㅠㅠ Thanks so much for the awsome video!! <333

[byuchu]

Amoeba sisters: exist
My science teacher: Y. E S

[chrstinejoyrocks]

LITERALLY GOT A MICROBIOLOGY EXAM TOMORROW AND WATCHED THESE IN HIGH SCHOOL BUT STILL HANDY IN COLLEGE

[natashaesquice]

This video literally helped me out for a test I have tomorrow. I didn't get a thing the teacher said while I was in class and yet I paid attention. The simplicity and clarity that this video had, made me forget that this test was going to be hard. It literally took all my stress out just seeing that it's that simple (I know it's more complex but I got it). Props to the ones who created and edited this video. You made my day. Keep it up :)

[Spurrr]

My entire Micro class was confused from a professor who cant speak english well. This taught more more in 8 minutes than she could in an hour and a half. Thank you

[StacksT]

How you guys decided to update this 2 days ago when my test is tomorrow is beyond me! God bless y’all for being on your A game lol💕

[tkurthyt]

why am i paying a university to test me on this when you can watch it on youtube for free....

[kristinaquilindo]

i study a bachelor in biology and personally think these videos give me a better understanding then the professors do, thank you for helping me through this mess

[freshtasharifi]

I love the way she uses these little game characters to explain it. Really helps. ❤