Popular Supplement Linked To Heart Disease

Many people take high-dose vitamin B3 supplements in various forms such as NMN, NR, nicotinamide, or niacin for longevity purposes. But a new study links Vitamin B3 to blood vessel inflammation and heart disease. Let's take a closer look.

Here are the links to the research papers referenced in the video:

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[silverpro]

i just started taking B3 and notice my depression is lifting and my thinking feels clearer.

[johnconcannon]

Who funded the study. B3 competes with statins.

[richardpellis]

Im just going to throw in the towel and give up. Seems like EVERY recommended supplement ends up with trials proving they dont work and actually cause other issues. Can't drink water. Its poisoned. Can't eat foods, their poisoned. Exercise too much, bad for you. Exercise too little, bad for you. 7 years into this health optimization journey and I've yet to come across recommendations that dont have counter arguments.

[tgferg]

B3 is being studied for glaucoma. 3 grams of nicotinamide for 12 weeks significantly improved visual field.

[suryaom-abrao]

Most studies say exactly the contrary of this video. So many people people had tangible benefits from taking Niacin. Strange to see a video contradicting the majority of other studies and also the experience of so many people for DECADES. Maybe the study in this video was financed by pharmaceutical laboratories who don't want people to free themselves from those highly profitable drugs they sell.

[Vegguit]

I have been taking 1, 250mg daily for 35 years. in the form of Nicotinic Acid.
Also been taking NR and NMN for about 5 years.
My cholesterol ratios are awesome and my calcium score is 0
Just an anecdote...
I am 61 an super-fit, low BP, etc.

Edit: I start because it was recommended in the "8 week cholesterol cure" book

Also, B3 has to be taken as Nicotinic Acid for cholesterol utility, Niacinamide is ineffective

[SteveSmith-zzih]

Who sponsored the Study - Statin suppliers?. Remember Doctors once said smoking was good for you, Butter was deemed a death sentence, probably allegedly margarine producers started that one. ALWAYS follow the money if you can!!!

[ChromePlatypus-]

Dr Stanfield, did you see the flaw in the old Niacin studies where they used statin based control groups. And when one study adjusted for this, it showed a decrease in MACE directly from Niacin supplementation. Additionally, Physionic mentioned in his review that 4PY being inflammatory was possibly linked to a gene mutation. Can we be tested for this mutation?

[landoishisname]

it's interesting, I'd heard some cardiologists say they were seeing improved outcomes with NMN supplementation in their patients, hopefully we get more evidence soon

[markpercival]

Dr. Brad, please share the section of the study that references the doses of niacin which were being taken by those studied. All I see on review of the studies referenced is their investigation of metabolites that they assume were related to excess B3. In fact they excluded those taking niacin supplements from their study. “Serum levels of the terminal metabolites of excess niacin, (2PY) and (4PY), were associated with increased 3-year MACE risk in two validation cohorts”. Am I wrong in thinking these metabolites are as likely to be reduced with appropriate B3 intake?

[chrissc-hit]

It has been going on for decades now: people have been conducting studies to show and demonstrate the supposed ineffectiveness of Niacin therapy for preventing heart diseases.

Listen, I understand at this point.

But the fact remains that, despite being ineffective, Niacin does lower LDL levels. It is a clear and measurable fact. Yet, no one even tries to explain how it is possible to lower one’s LDL levels without improving one’s cardiovascular health or preventing some negative heart events. I don’t know why people keep beating around the bush.

The issue isn’t really Niacin at this point; it is why the lowered LDL levels aren’t having any positive effect on heart disease prevention.

[barakav]

Brad is so happy, he proved his nemesis Sinclaire wrong.

[Battery-kfvu]

If the conversion of NR and NMN to niacin is the problem, then what about using liposomal forms instead, they should be absorbed directly by the gut and they still raise NAD. Then what happens with 4PY mmh no idea..

[lennygriffin]

I think we would need the lifestyles of the test
Fat, obese, smokers, SAD, heavy drinkers, ...etc ????...
Their are so many factors that we need to know about the test

[FreshGreenApples]

AIM-HIGH isn't a study of the effect of B3 on cholesterol. It sought to discover whether there is any ADDITIONAL benefit when ADDED to STATIN THERAPY.

[SharonPitman]

You’re just awesome, addressing this issue straight away and providing us again with great content. Cheers Brad! 🙌🏻

[greatawakecoach]

Thank you for this, Dr Brad. Is Niacinamide also included in this study?

[enalo]

Which form of niacin was used in the study, flush or non-flush cause the difference is huge?

[cubanadiense]

Ppl with kidney problems improve with niacin apparently. Maybe it is good when you use it for a particular issue it solves where it serves that extra purpose

[jacksonmississippi]

0:51 mark asks "Why now are we hearing about these possible links between worsening blood vessel health...". The answer may be because people like me can control their cholesterol numbers with 1500 mg of niacin per day at a cost of under $30 per year. Imagine how much big pharma losses when people like me aren't on statins for the rest of their life.