Rybelsus: Oral Ozempic? | Dr. Dan Obesity Expert

Have you heard of Oral Ozempic? It’s all over the news headlines as of late. Have you heard of Rybelsus? Same same, but different?

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A little while ago (okay, more like a year or two), I made a video comparing Ozempic to Rybelsus and talking about how it's kind of the inferior form of Ozempic. Is this still true?

Let’s get into it.

References:
▪️ Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, Rubino DM, Garvey WT; OASIS 1 Investigators. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 23:S0140-6736(23)01185-6. doi: 10.1016/S0140-6736(23)01185-6. Epub ahead of print. PMID: 37385278.
▪️ Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PMID: 33567185.
▪️ Rodbard HW, Dougherty T, Taddei-Allen P. Efficacy of oral semaglutide: overview of the PIONEER clinical trial program and implications for managed care. Am J Manag Care. 2020 Dec;26(16 Suppl):S335-S343. doi: 10.37765/ajmc.2020.88554. PMID: 33439582.

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Video Topics: medication for weight loss injection, benefits of prescription weight loss, medication management, medical weight loss, weight management, weight loss medications, weight loss injections, obesity treatment, medically supervised weight loss, rybelsus, ozempic, oral ozempic, semaglutide

#rybelsus #ozempicweightloss #obesitymedicine

[KulD-ix]

My dad takes it for type 2 diabetes. Just walks 20mons a day. Disnt change diet drastically and went from 100kg to a steady 76kg in 3 mths. Amazing medicine.

[trizhaay]

Taking Ryebelsus daily is a daily reminder that you are investing in your health. Maybe healthy habits will follow.

[praxisfurnaturheilkunde]

Vielen, vielen Dank für diesen Beitrag!!

[MrMwobbels]

I've been on Rybelsus for 3 months, from the 3mg for a month, then the 7mg for another month, and finally 7mg. I lost just over half a stone. In that time, I felt weaker, tired, and became exhausted very quickly, feeling unable to do anything. I lost my appetite. I went back to the doctor who checked my pulse and decided to give me an ECG and discovered i had an irregular heartbeat. The doctor put me on blood thinners because I was at risk of developing a blood clot, which could lead to a stroke. I asked if this could be anything to do with the rybelsus medication and was told there were no reports of any side effects to an irregular heartbeat. However, I decided to look at the manufacturers website and found that an irregular heartbeat was a listed side effect. I decided to stop taking the rybelsus medication and return to my original diabetic medication. Thankfully, with in 36 hours, my heart rhythm returned to normal. I did not feel tired, exhausted, and felt like a new man. My doctor is trying to persuade me to go back on the rybelsus medication.

[jacoll]

During the initial 60 days, I shed 30 pounds by using Rybelsus at doses of 3mg and 7mg. Yet, in the subsequent 60 days, I've observed no further weight loss while consuming Rybelsus 14mg, and my hunger levels remain unchanged. Is this lack of progress typical, and would it be wise to persist with Rybelsus 14mg?

[MrDreadsecond]

On the Rybelsus right now just 3mg because at the dokter we cant get Ozempic anymore, im a diabetes 2 patiënt and for me this stuff works wonders finally got my diabetes under control….slowly stopping my Gliclazide medication ( the not good medication with loads off side effects ). The only side effect i have is Some wierd nausia and sometimes dizzy. Atleast i got Some stuff that helps me.

[louiselarsen]

How does the absorption process work when administered orally? As I understand these peptides are considered too big to enter the blood through the intestine or stomach and that is why it needs to be injected? Is this the reason for the high dose of "oral ozempic"?

[judygundlock]

I wonder if the oral version will be any cheaper, considering there is no pen involved, which is expensive to manufacture.

[arnoldmmr]

I am diabetes type II. Do I have to take these pills for a long time? or this can be stopped after my weight is controlled?

[joycejones]

Excellent video, you covered all basis and I thank you.

[Aki-wqxh]

I have a question 😢​​ my appetite INCREASED rather than decreased whilst on Ozempic/ Rybelsus. I have tried both. At 14mg Rybelsus/ 1mg Ozempic. Any understanding as to why? It’s not super drastic but noticeable .

[andrewwilson]

I'm on Rybelsus, in Europe. My daily dose is 14mg.

Given the dosage in the trial was 50mg, should I expect my results to be significantly less good than using Ozempic?

I started on Ozempic but moved to Rybelsus because Ozempic became almost unobtainable. Since then, my weight loss has flatlined.

By the way, I also dislike the daily tablet. I have found it hard to consistently use it. My day starts with a glass of OJ or a mug of tea and habit means I often sleepwalk through making tea or opening the juice, so a day wasted!

[clarkkent]

Great video! One of the downsides to the injection is the long lasting nature after taking it. It is a long time to wait for side effects to resolve when starting or ramping up the medication. The doctor should be able to take much quicker action on the medication dose (including discontinuing) for a daily pill. Or maybe that is a downside due to the ease of quitting the medication. Did this study show a higher "quit" rate due to side effects than Ozempic/Wagovy?

[ellenflanagan]

I take Rybelsus for diabetes. While some weight loss is good, the GOAL should always be improved A1C levels and control of blood glucose.

[AK-lyfu]

I use Rybelsus, i habe type 2 diabet. It not work for me to get slim, but my sugger lewels is the best whit Rybelsus.

[afiyabegum]

Im obesity person want to lose weight my dr given me this medicine know im on 7mg my question is do i really really lose weight its unbelievable i have hypothyroidism do i need to go to the gym while taking this medication please help

[clipblocks]

rybelsus seems to be cheaper/cost the same as ozempic as well as being more available

[clarkkent]

Many GLP-1 medication patients complain that hunger suppression only lasts for a few days after taking their once-a-week injection. I have to wonder if a once-a-day pill would help with this.

[Aurora-qndx]

I have been put on "Trulicity " whats the diffrence with that and ozempic.

[rosaruiz]

To complicated to open this bottle.Don’t understand why