Virology Live #5: Attachment and Entry

As obligate intracellular parasites, viruses must enter cells to replicate, but they are too large to pass through the membrane of the cell. Instead, viruses are taken into cells by existing uptake pathways. In this session we discuss how virus particles attach to cell receptors, the triggers for genome release from icosahedral and enveloped viruses, and how membrane fusion is regulated.

Room Name: Virus

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Twitter: @profvrr

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– Who Am I? –

I’m Vincent Racaniello, Earth’s Virology Professor.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

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#microbe #viruses #lecture #COVID-19
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[listening]

0:20 Ben Franklin is proud of you and Daniel for collecting proverbs, Vince! 👍🕯

[nickgribble]

Thank you Vincent, I'm really enjoying the lectures but can't watch live due to work commitments. Love TWiV which a Chinese friend introduced me to last year. You have a bet appreciative worldwide audience. Nick (UK)

[Frithogar]

Thank goodness these are recorded - missed this live due to a power cut :(

[RUFUSKNAPP]

The Coxsackie digression was nice. Journal style, film camera picture.

[hugoed]

@VincentRacaniello - I think that you should keep the quizzes during the "session" because as well as being useful learning aid, it gives my brain a short break, I can digest the fantastic illustrations and animations, listen to your answers to question from participants and the smug/feel good factor when I get the correct answer!

To be serious for a minute, the last time I encountered virus attachment and entry was when diagnostic virology depended on virus isolation by cell culture and serology by CFT, maybe some HAI tests for flu antibodies and gel diffusion for rubella serology, so I am sure that you can imagine my pure enjoyment at seeing the diagrams and animations of virus-host cell interactions and hearing your commentary in this presentation. All your effort is greatly appreciated, thank you.

[JimmyGenome]

My cubicle is right across from Dr. Kuhn's office! funny how small the world is. For those unaware of him, he's the virology director at the NIAID-IRF.

[animalparty]

👍👍👍👍👍Love the Pete Townsend! Looks good on you! So appreciate that reference!!! You make science so cool!! You are the coolest!! Thank you Professor love your pods!!❤❤❤❤❤

[misterguyute]

I work in virology at a NYC lab and enjoy listening while doing bench work. Kinda meta.

[tatianabeastmode]

I love these so much! Thank you for doing them!

[Zerkzies]

If viruses never leave Fungi, how do they enter to begin with? Is it the same damage to cell wall like plants?

[r.davidyoung]

As far as I'm concerned... An epitope DOES refer to an episode of TWiV!! 🥳🙌👏❤️

[christersvensson]

Could there be a pH buffer effect on lysosome trafficking mediated by weak bases ?

“Hydrogen peroxide will react with Mn+2 ion in basic solution to produce MnO2 (a precipitate). In acid solution, the reaction actually happens in reverse and hydrogen peroxide will react with MnO2 to produce Mn+2. “

“a buffer solution contains a weak base and the conjugate acid of the weak base”