Inside ALS: The neurons behind the disease

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that mainly affects the nerve cells (neurons), which control muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and — ultimately — death. This animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

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[AdventureDaksExplores]

Update: She's with our Creator now in heaven

My mom have this ALS since 2007 to present. the doctor said before she's only got 3years and luckily she's with us until now. 12years since then and i hope more and more years to come for my mother :'(

[RolandMoone]

This is literally the best channel I've ever come across on Youtube. The amount of detail and the visual complements are just incredible.

[emilytarter]

I lost my nana, 3 years ago. I’m proud of who my nana was and i strive to carry on how she stayed positive threw 12 years of als. I will always love u

- ur pixie

[reshmaangela]

This is so informative... And reminds us being actually functioning and normal is a gift😭

[Jimmyeatshrimp]

Thank you this is literally the world's best animated and explained video ever I wish you and the creators of this video everlasting health and happiness may your families and grandchildren live long fulfilling lives because you deserve the world and nothing less. I love you.

[onemoremarble]

This disease is so complex, I understand why they are battling to find a cure or a treatment. Good concise summary.

[aidenblack]

All I know is that Mitochondria is the power house of the cell

[vidusia]

My mother was diagnosed with ALS about 2yrs ago. Watching her suffer is the hardest part. Through each stage everything gets harder and harder and it hurts k owing that theres nothing you can do but watching them die slowly. 💔

[maelleamand]

Thanks to the person doing the voiceover and for the entire team behind the video!

[danistor]

i hate this disease so much. Its SO sad, for the person who suffers is and to the people who loves them. Its literally a torture, it makes me so mad

[philkyaw]

THIS IS SO HELPFUL
The amount of detail, smooth animation and information makes this very helpful for this school project i am doing on MND/ALS

[alondragutierrez]

this shit killed my grandma it was the most saddest death i've ever seen. I loved her so much.

[Electroblade]

The Animation Is Extremely Easy To Praise

[马可波罗包]

One of my committee professor died of this disease yesterday. May the soul Rest In Peace.

[Chevalier]

I'm happy because everyday more people are searching for a cure for ALS. Thanks Nature for your video, was very illustrative.

[jaovanny]

Proteins that build up are what's causing the traffic jam into the nuclear port. Maybe start by finding which protein and use an antibody to remove them, also maybe find a way to sneak past the nuclear port thus minimizing congestion. Wish I was a scientist, instead I'm a hairstylist.

[meganmalicki]

My Grandmother got ALS. She had 4 children. 3 of the 4 have ALS, including my Dad who was just diagnosed on Monday.

[aarondavealvarez]

🎯 Key points for quick navigation:

00:01 *🧠 ALS is a rapidly advancing neurodegenerative disease that leads to paralysis due to motor neuron deterioration.*
00:31 *🧬 The cause of ALS is often unknown, but genetic factors can play a role in some cases.*
00:58 *⚙️ Protein accumulation due to faulty transport systems can be toxic to neurons and contribute to cell death.*
01:32 *🔍 ALS affects DNA repair processes, leading to increased neuronal death.*
02:03 *🛠️ Damage to the transport machinery of neurons disrupts communication with target cells, contributing to dysfunction.*
02:36 *🧪 Other cells, like astrocytes and microglia, play significant roles in either protecting or damaging motor neurons in ALS.*
02:50 *💊 Further research is needed to identify the specific processes causing motor neuron degeneration for potential drug therapies.*

Made with HARPA AI

[mohammadabouleil]

My dad had it from 2002 till 2004... past away from it.

[kamikaverma]

I am making the project on This topic ... And this video really helping me a lot ☺️ .
Nice 3D explanation 👍🏻❣️