Pernicious Anaemia : Definition, Pathophysiology, Clinical Features, Diagnosis, Treatment (HD)

Topics Include:
- What is Pernicious Anaemia
- Pathophysiology of Pernicious Anaemia
- Genetic Factors
- Auto Immune Factors
- Antibodies Against Parietal Cells
- Antibodies Against Intrinsic Factor
- Blocking Antibody and Binding Antibody
- Site of Gastric Atrophy
- Clinical Features
- Lab Diagnosis
- Schilling Test
- Blood Picture
- Bone Marrow Findings
- Treatment and Dosage of Deep Subcutaneous/ Intramuscular Vit B12 Injection

Hope it is helpful . - Dr. Rabiul Haque

[rishikagupta]

u r the best teacher pls keep uploading videos ....in 2020 also ur lectures are helping me n many more medical students

[esterherschkovich]

Oh gosh hate the getting old bit!I work as a Nurse+its hard going, need injections 2 monthly..fatigue!Thank you for your explanation.

[taooflovepassionandcomedy]

Thank you young man I shall have some very stern words with my doctor you have told me some thing no Doctor in Australia has ever mentioned.

[elainec.s.]

Thank you Doctor. Will listen to other video's. I have pernicious anemia and the B 12 def. I was in my early 30''s when it was found. When you mentioned the thyroid factor. It is in my family. I am trying to find out why I need to inject every 8 - 10 days. Again, than you so much.

[lindadahlen]

Your explanation is very thorough. Thank you very much. It will help with my treatment plan of PA diagnosis and other autoimmune issue going on. I have senile osteoporosis also at age 59. Now I know the relation of osteoporosis, high calcium in my blood and hyperparathyroidism. I will talk with my doctor about this correlation. Thank you again!

[mwazanjibanda]

your lessons are super helpful, I understand everything clearly when you tech...thank you very much

[esterherschkovich]

Why put thumbs down?, When it's an informative video!

[dr.mjwesley]

Awesome job. I'm preparing for board wanted to go through haematology real quick. Your videos helped me a lot. Every point is very crisp and clear. Please keep uploading more. Thank you so much for making it, Thank you for making it free as well. God bless you!

[norxgirl]

good info....from what I am learning, folate/folic acid, which is in most processed foods these days, can mask a Vitamin B12 Deficiency.  Please see Sally Pacholok's _Could It Be B12?_

[dubious]

Thank you so much for making these videos! I am currently taking a course on the pathologic basis of disease and your videos have helped so much. You are a great teacher and I sincerely appreciate your generosity in sharing these videos with all of us.

[ninjanicnic]

Pretty good but not all PA will present mesoblastic and glossitis or nerve damage /neuropathy.
Also as in all autoimmune patients may not have antibodies at time of test but may develop later or not but still have PA .
Gene mutation may be cause .
Loading doses should be until no further symptoms.
The monthly or 3 monthly is not enough for reversal of symptoms or healing nerve and tissue damage.
The maintenance dose is just enough to keep the person alive but with no energy and still in chronic pain .
Shillings test no longer done .
Look at active B12 tests for all low B12 (non diet related)
MMA homocysteine and to a degree MCV (but this may rise and fall with other factors and not always be high Evan with a diagnosed PA)
Better than some information but still flawed .

[aliciamilam]

Wonderful man u are . Can u cover herbs for these anemia.. rosemary helps with pain.. for ssd.

[gautamil]

He didn't talk about one more C/F which is Dyspepsia as a result of achlorhydria .Achlorhydria occurs because of reduced HCL production as there is gastric atrophy of parietal cells and we know parietal cells secrete HCL hence achlorhydria and thus Dyspepsia. :)

[felixkamugisha]

Thanks Dr Rabiu for your nice teaching videos. God bless you abundantly! Fr. Dr. Felix

[purposewithoutlimitstv]

Thank you. How long does it take for B12 supplementation to see healing in the nerves and motor and sensory function? Year?

[PrinceKumarsHere]

Thanksss a lot sirr.. from AGMC student

[phurbutsering]

Thank you for the great video. Helped me understand pernicious anemia for my exams

[laila]

your lectures are really helpful - greetings from UAE

[PoojaPatil-qztv]

Thank you so much sir.... Your videos are really very helpful.. 😇

[docnature]

i would like to suggest u sir to go through all points mentioned in harsh mohan book of pathology... it will b very helpful for us then.. thanks for teaching us sir !