Pernicious Anemia (Rare Cause of Vitamin B12 Deficiency) | Causes, Symptoms, Diagnosis, Treatment

Pernicious Anemia (Rare Cause of Vitamin B12 Deficiency) | Causes, Symptoms, Diagnosis, Treatment

Pernicious anemia is an autoimmune condition involving production of autoantibodies against the parietal cells of the stomach, which produce intrinsic factor that is required for absorption of vitamin b12. In this lesson, we discuss the risk factors, the causes, and the signs and symptoms of pernicious anemia, along with how it is diagnosed and how it is treated.

I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!

JJ

**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

*AFFILIATE DISCLAIMER: This YouTube Channel uses affiliate links and may earn a commission from associated sales.

*IMAGE DISCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only*

-------------------------------------------------------------------------------------------------------------
For books and more information on these topics

Check out the best tool to help grow your YouTube channel (it’s helped me!)

------------------------------------------------------------------------------------------------------------
*Check Out Some of My Other Lessons*

Medical Terminology - The Basics - Lesson 1:

Infectious Disease Playlist

Dermatology Playlist

Pharmacology Playlist

Hematology Playlist

Rheumatology Playlist

Endocrinology Playlist

Nephrology Playlist

Fatty Acid Synthesis Pathway:

Wnt/B Catenin Signaling Pathway:

Upper vs. Lower Motor Neuron Lesions:

Lesson on the Purine Synthesis and Salvage Pathway:

Gastrulation | Formation of Germ Layers:

Introductory lesson on Autophagy (Macroautophagy):

[rdance]

It's very hard for doctors to diagnose. NONE of my 5 specialists could, since none of them ordered MMA or Hyc. My Endocrinologist is the one who gave me the clue, so I could do it myself. As we were ending a regular check up, he said that my MMA was slightly elevated. Like I stated, it was never checked. It was a Freudian Slip. He meant that my blood markers indicated low B12. I found this odd, since I had been complaining that I had EVERY low B12 symptom but I had been injecting B12 for over 10 years and I knew my serum levels were normal. This was enough to get me learning about metabolic pathways. In my case it was functional B12 deficiency due to MTHFR, DHFR and NAMPT SNPs and YES I figured that out too. They had me on Methatrexate, Sulfasalazine and Folic Acid. (NOT GOOD!). Since "HMT" requires 5-Methylfolate, a lack of Folate causes decreased activity of HMT. This decreased activity can actually drive serum B12 up, since it's not getting used. This is where doctors and patients often get confused and why MMA and Hyc is so useful. Since MTHFR is B2 dependant, Riboflavin deficiency can also lead to the same set of symptoms. Even B3 (Niacin) can lead to these symptoms because DHFR and MTHFR, both require NADPH, a metabolite of NAD. One day, they will standardize at test for SAM/SAH ratio. This will prove to be very useful.

[rdance]

I injected Cyanocobalamin for over 10 years, until I learned about my Methylation problems and how these problems were affecting my liver. Purely theoretical but I found it curious that people supplemented with a form of B12, for energy, that is formed with Cyanide, when Cyanide is known to inhibit Complex 4 of the Electrol Transport Chain, the very process responsible for energy production. It also has to be filtered out by the liver, the "Power House" of the body. Once I learned that, I switched to Hydroxocobalamin, until it got harder to find. Now, I inject Methylcobalamin.

[facetiousgirl]

Great video! I've been struggling with the concept of megaloblastic anemia all semester. Thanks for putting it so simply!

[waelfadlallah]

Thank you so much sir for those expert videos. I kept track of your videos since the very beginning and i'll still excitingly wait for new releases 🙏

[cbryce]

Many of my female relatives on my mother's side had PA, several died young, before knowing what it was. They didn't know what PA was until my grandmother's generation. Thank goodness for science.

[rdance]

I'm not a doctor or even an expert but that's the first time I've heard Methionine Synthase refered to as HMT. I've seen MS and MTR but never HMT. I guess you learn something new every day.

[terrieseverson]

My grandmother was diagnosed with PA at Mayo Clinic in the early 1940’s .Although none of her two daughters inherited that particular disease they did have celiac disease and RA in their early 50’s. Me, my sister, and my oldest daughter all have Celiac disease and I was the lucky one to get RA as well. To date none of us have PA .

[plarkin]

See Peter Osborne yt
Hes very knowledgeable about nutrition.
I believe a cause is Non Celiac Gluten Sensitivity....I figured out, on my own I have this.
My aunt had pernicious anemia then I realized that my Mother had NCGS too. The villi become harmed from gluten, then one is not able to absorb nutrients properly.
Be blessed❤

[klattalexis]

My paternal grandmother suffered from Pernicious Anemia for a very long time but in the end she died from Leukemia. Is there a link between the 2 diseases?

[McSlobo]

MCV isn't necessarily high if there are other conditions such as iron deficiency.

[Renofirefly]

I jyave Hereditary Hemochromatosis and Macrocytosis Anemia. My B12 was normal but my folate was low. I get weekly phlebotomy and since my treatment started, I've been having pain in my sleen. Im starting to understand now that the large blood cells are putting lots of stress on my spleen. Its interesting to know i can still be deficient in b12 with normal levels.

[kimoniaa]

Thanks for the video. this is really very well explained. My question is, given the Schilling test is now obsolete, after determining it is Vit. B12 def. anemia, how can the cause be identified? (autoimmune (impaired absorption) vs nutritional deficiency)?

[suzannebrach]

I have methylation issues with b vitamins. Just diagnosed with pernicious anemia which I suspect I’ve had for years based on markers. I have other autoimmune conditions and type a blood.

[ilmendo]

I have celiac disease, polymorphism in the mthfr pathway, eosinophilis hypothyroidism, EoE, previously I had moderate homocysteine with high mcv (104), Mch, metabolic syndrome ( triggered with the gluten free junk food), bile acid malabsortion.
Can you have Pernicious anemia with Vitamin B12 at 300 based on my list of chronic conditions ?

[jasanders]

THIS GUY IS 😮OTT
I HAVE SOME MEDICAL TRAINING, 😂GOD HE HAD ME BAMBOOZLED.😮😮😮😮
I HAVE F.A. OR B12 DEFICIENCY.
HIGH MCV.
ETC.

MY DOCTOR JUST GASLIGHTS ME ON IT ALL.

DIFFERENT DOCTOR, PUT ME ON 3 MONTHS OF FOLIC ACID TREATMENT.
BUT, DIDN'T FOLLOW UP ON ANYTHING 😢

[lorenzoskyhawk]

Brilliant! now I understand my condition much more. I depend on one injection every three months... I have a question, normally I was receiving Hydroxocobalamin in the UK and since I'm in Asia I have received one injection of Cyanocobalamin is this okay or should I only receive Hydroxocobalamin? Thanks!

[iloveranch]

you should do a video about POTS syndrome (Postural orthostatic tachycardia syndrome)!!!
there aren't many medical videos about it and needs more awareness :)
love your videos btw!! have a nice day :)

[PixelGem]

I knew my b12 was low, but I never really got serious about taking a supplement. Well I have all of these symptoms, so I will be taking better care of me from now on 😅

[heather]

I think I might be dealing with hymoletic and pernicious anemia. I have one on my Mum's side and one on my Dad's side. I've been struggling with this since I had my son 20-years ago. My hemoglobin dropped to 50 and they were stumped as I did not lose any more blood than a regular delivery, they claimed (I had a c-section). Since then, Ive been diagnosed with borderline hypothyroidism, B12 deficiency and now I've discovered this G6P deficiency from researching why my body can't handle a henna hair application. My urine was the colour of black tea last night and I had an extreme headache, dizziness, and nausea. How on earth can I sort this all out.

[xocheenahox]

Can having too many b12 buttocks injection cause this too?