Lipid Experts: LDL DOESN'T ALWAYS Clog Arteries

In today's podcast we have Dave Feldman, Nick Norwitz and Adrian Soto-Mota, who just published new evidence on the role of LDL in cardiovascular plaque in people who fit the criteria of LMHR.

Long but worth listening, Dave, Nick and Adrian share tons of interesting perspectives.

Check out more of our perspective on LDL:

Check out our latest video on Apple Cider Vinegar:

Check out Nick's Egg Video:

Check out Nick's channel:

Check out Dave's channel:

Research referenced in the video:

[edwinGuyle]

Doctors have been telling my mother to take meds for her high LDL for years. She did recently have a heart attack but was told after testing that she had very little plaque build-up and atherosclerosis.

Her heart attack was caused by mental stress at 70 years old, and they still tried to give her statins even though her BP is around 117/70.

[glenntimberlake]

I was really glad to see you have these guys in this podcast. Good conversation.

You really need to consider the lifestyle changes.
I am glad it was mentioned.

If people really want to lose weight they need to be working on building muscle mass. You want to lose unhealthy “fat mass”. Not “weight.”
You don’t want to lose muscle mass.
…
Build muscle and use muscles and you will burn calories and fat loss will occur. And the muscle mass will increase which will improve their body functions and give the confidence to keep going. Also, people will feel better and that will encourage them.

Get the diet under control as the other major thing that has to accompany the work on muscle strengthening and muscle mass gains while also losing fat mass and increasing energy and a better chemical balance in their brain.

When he said people don’t know how to change their lifestyle, he nailed it. Many don’t understand because it has never been explained in ways they can understand and but in to.

[firstchoicefarm]

As an extreme LMHR, it's wonderful to have more and more constructive discussion about this phenom. I hope it leads to doctors working with patients with proper treatments with scientific reasoning.

My PCP saw my numbers when i asked for a CAC baseline. She said she wouldn't touch me and sent me to a cardiologist. He listened to me but was just then focused on wanting me on a statin to bring my LDL down over 350. I brought up LMHR and he just went to the AHA and read about their one case of someone they called a LMHR (nothing to support he was). The cardiologist was not helpful and i fired him after getting the baseline CAC score.

[paulasamec]

I’ve got a short soundbite: UNOXIDZED LDL alone does not cause any metabolical disease! On the contrary in my view, it’s important for so many functions in the body: the immune system, the brain, healthy membranes etc. so that people with high LDL reach a high age.!

[patcoviello]

Okay so at 77 yrs old lost 23 lbs LDL went from 210 to 136 HDL 36 tryglcerides, 136 on Mcdougall starch solution. My doctor is pleased I feel a lot better.
On keto gained 23 lbs and had high lab numbers. Not for everyone. As we are all individuals, and although some things may be genetic, I do believe a lot of results point to the food and life style.
By the way at 77 I swim and walk. Not too much sitting!

[gungagalunga]

My LDL 263 after 6 months keto. Every other indicator went into good range. Including my liver function tests completely went back to normal

[meanwhile...]

'Massive and groundbreaking' is not hyperbole. Couldn't agree more. Waiting for the medical and insurance industries to catch the heck up. GREATLY appreciate you all for your tenacity. Thank you!

[nassermj]

I believe this, still will be cautious

[MichaelDevlin-sr]

Gentlemen. I love this conversation. I still see a lot of heart disease so I know we have to keep searching for answers. Statins have not solved the heart disease problem.

Hello sir, I want to share my story and want your help. I am 35 year old male. Three years ago I started keto (primarily to reduce weight ) and it worked exceptionally well. I was overweight by about 10 kg. Within 6 months, weight reduced and body transformed. Every thing was perfect. I was doing ghee (clarified butter), eggs and chicken only (all organic) and very occasional red meat. Thereafter (about 8 months into keto) I increased red meats frequency and one day experienced angina (heavy ness in left arm). Was not sure it was angina or something else. Stopped red meat and continued keto. No symptoms thereafter. A weak before that episode, I also experienced foamy urine (but no kidney issue or any protein in urine) which also went away. I continued keto thereafter. Now again about a month ago, I introduced red meat (mutton only) and I started experiencing foamy urine first and then angina. This time the symptoms were aggressive along with dizziness. I discontinued keto a weak back and symptoms are quite improved. Not gaining strength to visit cardiologist. I believe I have blocked arteries. What went wrong. Not able to understand what to next.

[glenntimberlake]

Great discussion.

A great step toward the right direction. Thanks.

[Djangoat]

This is an excellent discussion but I think it misses a key point. There is conclusive evidence that once harmful LDL particles (Apob etc..) enter the lining of your arteries, it kicks off a cascade of inflammation leading to harmful plaque etc...The study indicates that if you're metabolically healthy, high LDL does not necesarily mean that your arteries will let the LDL enter the lining and cause inflammation. However there is evidence that many other factors not just metabolic syndrome, but also genetics, oxidative stress etc.. can make the arteries susceptible to letting the LDL enter. Therefore to all the metabolically healthy folks not worried about high LDL, I would strongly advise to first get a calcium score or even better a CT Scan with advanced imaging capable of identifying harmful soft plaque. If it shows no plaque you're probably good to embark on your high LDL adventure, and probably re-retest a few years later to be sure. Otherwise you're in the group of those who (despite being fit and healthy) have 'LDL sensitive arteries' and should think hard about slamming down that LDL/Apob to reduce inflammation. Ford is metabolically healthy and is a proponent of this..he's mentioned several times on other talks that he has plaque and is on a low statin dose (I think he tried to go into that topic at 49.55 but the others didn't follow) . Peter Atia, also a respected person in this field and metabolically very healthy but with a genetic predisposition to arterial inflammation uses Apob lowering drugs.

[davidbarnes]

Great content. Can you ask the researchers for comment on the following and cover it in a future video?
It would be interesting to know what the breakdown of LDL particles was in each group (I realise that they did not have this information). The lipid profile of the LMHR group would suggest a greater proportion of lbLDL than that of he Miami group. If that was the case does this mean a) that the ApoB particle count was lower due to the larger percentage of ldLDL particles and b) Did the larger lbLDL particles (and less % of sdLDL particles ) provide less atherosclerosis risk/volume.

[danmoore]

This was very interesting and helped me understand a variety of topics better

[khairulshiddiq]

Unfortunately, big pharmas and food companies won't let this extremely important study to be accepted by many people in the world in the timely manner.

[hmlxur]

Yes with the magic statin pill introduced in 1987 and to date CVD continues to increase, life style changes is the key for better health, in my opinion.

[PTracer]

Looking forward to hearing dr Brewer discuss CIMT with some of these others

[RobertWinter]

Great discussion.
I'd love to see Dave's hypothesis tested regarding the number of people who could become LMHR under the right conditions. The quickest test would be to start with fit and active people, but I believe even people with metabolic syndrome will convert given sufficient time. LMHR is rare now, but isn't it possible that it has been our normal phenotype for most of the last two million years?

[jon]

Please answer this question-wouldn’t you agree that when a patient is thought to have FH, this is not tested and just assumed. This happened to me after adopting a mostly carnivore, no seed oil diet and losing weight until I dug through my records and found a low LDL report in my late 20s

[tonynes]

Boy this sounds complicated 😮but interesting.