What neurotransmitter does caffeine affect?

When you sip that cup of coffee or tea, caffeine quickly makes its way into your bloodstream and crosses the blood-brain barrier. Once there, it acts as a central nervous system stimulant, blocking adenosine receptors. Adenosine is a neurotransmitter that promotes sleepiness and relaxation, so caffeine’s interference with it keeps us feeling awake and alert.

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