Monosodium glutamate

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This makes sense to anyone who has studied biochemistry before, but we get lots of people in the comments section who have no clue about what amino acids or proteins are and how they are synthesized and metabolised. Lots of people just 'read' conclusions from research papers that are clearly very technical and randomly come to their own 'conclusions' about what it all means.

Amino acids are used in every living organism to synthesize proteins. Glutamic acid is just one of many. We synthesize some amino acids, and require some basic ones (about 8 or so).

An slightly accurate way of thinking about amino acids and proteins would be to think of a protein as a long pipe with various joints, elbows, attachments like valves or meters. Each amino acid is a part of the protein, so each joint, each valve, each meter, etc that is attached one end onto the other - forms the protein at the end. (This is a gross simplification... if you want to think of it even simpler, but less technically accurate, you can call it a wall with 20 or so different types of bricks in it).

Glutamate is but one type of 'joint' in a protein (amino acid) sequence.

Some amino acids are used by the body as neuro transmitters, but most are for protein building (and when we say protein, we mean structural components of the living being, not just some random piece of protein that floats around as filler - even albumin has electrolyte and water binding functions).

Then there's the blood brain barrier, that most people are confused by.

It's a membrane that essentially separates the blood from the brain, so the brain's fluid environment is more controlled and less fluctuant that the rest of the body. It is partially permeable, so certain antibiotics, water, and some electrolytes can pass through (electrolytes are controlled via pumps, due to how the membrane repels charged particles, which is why certain anibiotics don't pass through while some do - significantly limiting treatment options when there's a bacterial infection that manage to penetrate the Blood Brain Barrier (BBB).

Glutamate is a charged particle, so unless it is transported across, it's not going to just slip through anywhere it wants.

At the end of the day, it's just another amino acid that the body has evolved to sense via the alimentary system to stimulate our behavior and control what we put in our mouths. Just like sugars, salts, alkali/bitter chemicals, acids/sour chemicals.

It is meant to taste 'protein' that would otherwise not be tasted. If not for glutamate and the way we taste it, we wouldn't be able to automatically tell if a food source contained protein without food labels. And it is good to eat it as long as it is in control, like chocolate, sweets, salt, fat, etc.

Soneoak

this is not what i have expected when i searched "e621"

echofluwuff

Man oh man, on my quest to determine what is/isn't healthy, the list of OKAY/GOOD things just keeps growing (and it includes a high-sodium diet, saturated fats, cholesterol).
*SUGAR* remains villian #1.

AAAlpherior

MSG is good at helping those with sickle cell anemia absorb iron in various meals (beef consumé, liver, etc.)

camillebambi

Hi dear Osmosis, I am a medical student and this channel is the best medical channel to, may you upload physiology and biochemistry videos!
thanks

ehsanullahnoori

I only searched this up because of uncle roger saying why he don’t use msg msg is for everything

nightimw

Having too much salt can be bad, but having too little is far worse for your health.

xaius

The Ajinomoto Group (food corporation) would be proud of your over simplification regarding the assurances of safety. However, I recommend everyone looks deeper into the existing research of excitotoxins, like MSG and Aspartame, and the real damage they can do. A great book written by a very experienced Neurosurgeon, Russel Blaylock, called "Excitotoxins", dives much deeper into the research and shows very clearly how free glutamate can bypass the BBB (which does not protect the entire brain) and cause severe damage to the brain causing several Neurodegenerative diseases. It is very well referenced and for those that want to understand this topic better you should pick up a copy, along with his other book "Health and Nutrition Secrets that can Save Your Life." Just a suggestion. That all being said, I love Osmosis and have found great value and education from your content.

above_genetics

why do we store glutamate in pounds while we need and eat it in grams?

jackculler

I remember this was said to be carcinogenic. Probably not true after all.

aryamonmukherjee

Don’t trust any of those organizations

Lauraleitsch

Where am I able to find some of the sources that were used in this video?

higuys

Monosodium glutamate is the issue. From personal experience before I looked it up I had no idea what MSG was. And how widely it's talked about. I get mild headache after eating Monosodium glutamate

Strength_In_Wisdom

That’s nutritional science for ya. Coffee is good, coffee is bad. Fat is bad, fat is good. Carbs are good, carbs are bad. Butter is bad, butter is good. Chocolate is bad, chocolate is good. Alcohol is bad, alcohol is good. 😠

sl