Vitamin D reduces autoimmune disease

Come on government, change the out dated guidelines. John's text books, free downloads,

Vitamin D regulates a wide array of genes involved in inflammation and immunity,

inconsistently associated with reduced risk of several autoimmune diseases in observational studies

Active form of vitamin D regulates genes, inflammation, acquired and innate immune responses

Dietary marine derived long chain omega 3 fatty acids decrease systemic inflammation in some autoimmune diseases

Evidence is needed on whether omega 3 fatty acids lower the risk of developing autoimmune disease

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

To investigate whether vitamin D and marine derived long chain omega 3 fatty acids reduce autoimmune disease risk.

Vitamin D and omega 3 trial (VITAL), a nationwide (US), randomized, double blind, placebo controlled trial

N = 25, 871

consisting of,

12, 786 men ≥50

13, 085 women ≥55

18,046 non- Hispanic white

5,106 black

2,152 as other racial and ethnic groups

Mean age was 67.1

INTERVENTIONS

Vitamin D (2000 IU/day) or placebo

Omega 3 fatty acids (1000 mg/day) or placebo

Participants self-reported all incident autoimmune diseases from baseline to a median of 5.3 years,

these diseases were confirmed by medical record review

In the vitamin D arm

Treatment group

123 developed an autoimmune disease

Placebo group

155 developed an autoimmune disease

Hazard ratio 0.78

P = 0.05

In the omega 3 fatty acids arm

Treatment group

130 developed an autoimmune disease

Placebo group

148 developed an autoimmune disease

P=0.19

CONCLUSIONS

Vitamin D supplementation for five years

with or without omega 3 fatty acids,

reduced autoimmune disease by 22%

Omega 3 fatty acid supplementation

with or without vitamin D,

reduced the autoimmune disease rate by 15%

(not statistically significant)

The clinical importance of this trial is high because these are well tolerated, non-toxic supplements,

and other effective treatments to reduce the incidence of autoimmune diseases are lacking

Autoimmune diseases

Rheumatoid arthritis

Polymyalgia rheumatica

Hashimoto’s thyroiditis, too little thyroid hormone)

Psoriasis

Type 1 diabetes mellitus

Multiple sclerosis

Lupus

Inflammatory bowel disease (Crohn’s Ulcerative colitis)

Addison’s (too little of cortisol)

Grave’s (too much thyroid hormone),

Myasthenia gravis

Pernicious anemia

Autoimmune vasculitis

Celiac disease (gluten protein from grains)

Inflammatory autoimmune response to self-tissues

Third leading cause of morbidity in the industrialized world

Chronic conditions

Increasing prevalence with age

Lack of effective treatments

More about the VITAL RCT

VITamin D and OmegA-3 TriaL (VITAL)

A randomized clinical trial, US based

N = 25,871

Investigating

Daily dietary supplements of vitamin D3 (2000 IU),

or omega-3 fatty acids (Omacor® fish oil, 1 gram),

reduces the risk of developing,

cancer

heart disease

stroke,

in people with no specific history

5-year intervention phase (study pill-taking, median 5.3 years) has ended

post-intervention observational follow-up, ongoing

[marycollins]

I was diagnosed with MS at 36 in 1995. Reversed it. Still symptom free had a child at 41 no complications. He's a healthy 21 year old now. Diet supplements outdoor exercise. Sunshine and nature hikes are key to my life. D3 with K2. I have added kraut kimchi natto etc

[TheKitty]

An ounce of prevention is better than a pound of cure. Thanks, John, for the update on the importance of Vitamin D and daily care of our health.

[artusdemontalembert]

As usual, interesting and beneficial. I started 7 years ago supplementing with vit D (10 000 Ul) a day and omega 3.
Hoping doing this to stop arthritis which was my problem. At that time I had asthma since 1980 and high blood pressure since the age of fifty.
After three years, these two pathologies vanished, and in addition I stopped having any cold or influenza-like illness, which I used to have during winter time.
I am not vaccinated because I had an anaphylactic shock three years ago at the end of a surgical operation and nearly died.
I got the Delta variant end of December 2021 and the omicron BA2 mid February, each time in a mild form. My age : 80 years
and in very good shape, (until now). My case goes along with your point.

[joecity]

Your message about Vit-D and K2 encouraged me to get my 25 OH D level done and proceeded to titrate up to a decent level (200 nmol/L after 16 weeks at 9700iu d3/day). Best winter in years, thank you. Don't forget that a lot of GPs are no good at nutrition. Mine tried to talk me into saving the $38 for the test and when I pushed him to give me a target level and dosage he just said, 'this conversation is over'. i can forgive him for not reading anything since med school, but not for not listening to me tell him what's in recent medical journals of the sort to which you refer in your talks. Bravo.

[brianmoran]

Hi Dr. Campbell thank you so much for your video. I was diagnosed with Ankylosing spondylitis two years ago and I was having a terrible time with my health and day to day living. My specialist put me on Biologics which were making me sick and feeling even worse all the time. I heard you talk about vit D in another video about 6 months ago and I have been taking 6000iu daily and I am now in remission and not taking any biologics anymore. My new specialist just has me on natural therapies now and I can't remember the last time I have felt this good

[westfield]

For 30 years my kind selfless mother suffered from debilitating rheumatoid arthritis. I wish I had know this before. She passed away March 11. I love and miss you Mom. ❤️❤️

[biancamuntean]

You have been of immense help through the epidemic and your posts are soooo very welcome, Dr Campbell. Thank you!

[christytucker]

Started watching yo in Spring 2020, began taking vitamin D soon after.
Vit D level remains in 80’s. No sickness of any kind. I’m in Florida.
Thank you for all of your work. You are greatly appreciated.

[nikthefix]

I played guitar for a living and back in 2018 I started getting pain in finger joints. It was getting progressively worse and made the job difficult to say the least. Much later I started taking Vit D and K2 for Covid reasons and now my fingers are pain free and as nimble as they were when I was 18. It took about a year of taking the supplements before I realised the problem was resolved - at least for now.

[davidjfraser]

As a retired marine engineer I have always been trained and worked to the mantra that prevention is better than cure.
Therefore our maintainence was always preventative for instance, changing oils and filters within a certain running time.
This meant that sea time was keep to a maximum as there was little break down maintenance caused by lack of maintenance.
The same principle can be applied to many scenarios in life, such as the human body.

[KyleBreeth]

I've been noticing this for a long time, was diagnosed with Multiple Sclerosis at 16 years old. and My doctors would always tell me to take vitamin D supplements. I was always on the very low side. They would give me weekly strong doses of it once a week over 75, 000. Now i just take 10, 000 a day and it really helps! Vitamin D is super important 100% helps so much

[tzviasegal]

I started taking vitamin D liquid drops some 15 years ago to combat menopause related hot flashes and night sweats and they stopped immediately. Literally overnight. The ear infections I regularly got since childhood stopped. The common colds I regularly had almost stopped- at this point it's been at least 7 years since my last cold. And despite being an 'essential worker' and having to come into work multiple days a week and having to see different people in multiple offices (in IT), out of the up to 14 people in my work team, only one other person and I have NOT had Covid despite being around the others regularly. With no noticed negative effects, I see no reason NOT to take vitamin D (I do take K2 as well).

[aprilgabutina]

Back to basics :) Outdoor, nature, eating whole foods, homecooked meals, relationships, etc. Thank you Dr. for sharing this study.

[myclassmate]

I had Graves’ disease for 15 years, tried getting off medication multiple times, the disease kept coming back. I began supplementing vitamin d3 and then got off medication. My thyroid levels have been normal for over 3 years. I believe 100% vitamin d3 made this possible.

[royjackson]

As someone who developed MS over 20 years ago, I can tell you what Dr Campbell says is almost certainly true.
I began Copaxone disease modifying therapy in 2007 - 2 years after being diagnosed - yet I noticed a BIGGER improvement when I began taking vitamin D3 by my own choice.
In the end my specialist ADMITTED it HAD helped me.
I also take fish oil supplements and consume oily fish regularly.
I stopped taking my MS injections around 3 years ago and have felt better since doing so, though that isn't an automatic recommendation.

[David_Camerwrongun]

Certainly seen improvements in psoriasis and Musculoskeletal symptoms since taking D3 supplement

[StreetFighter]

I was taking 2, 000 IU daily. But when COVID started, I bumped it up to 5, 000. I have not had so much as a sniffle since January 2020.

[tradermunky]

I started having issues with my skin. Psoriasis and eczema. Couldn't get rid of it for years, trying different creams, changing diet, etc. Until I started taking a quality 5k IU vitamin D supplement. Within a few weeks it was all gone.

[GotMountains]

You sir, are the Sir David Attenborough of medical studies. Thank you for the gift of simplicity and clarity.

[maryriley]

As the movies say, "Where have you been all my life?" This is really good information about which I have been largely ignorant. I'm 73 and should have been taking these vitamins long before, but better late than never. Thank you for your enlightening videos where you get right down to the nitty gritty.