The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.

#Aging #DavidSinclair #Longevity

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Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support

Links:

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

[Gadinata]

I have been following Dr. Sinclair since I was 33.
I am 30 now.

[RickyConnelley]

So glad he made a podcast! The fact we can listen “for free” to a Harvard professor teach is amazing!
We live in cool times for self learning

[jeffmiddlebrook]

Thank God for leaders like David who genuinely want to help mankind.
My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence.
We plan to share this information to whomever will listen and become disciples of longevity.

[jimparsons]

He takes 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise.👏👏👏👏👏

[odmineypiju]

I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible!

[microwaveengineer]

The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great!

[zalareverie]

I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better! <3

[LongevityPlan]

We’re super jazzed David has his own YouTube channel and podcast now! The future is looking great!

[edison_ryan]

I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes!

[sneakers_guy]

Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍

[tonyamckimmy]

On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward.

[teddy]

I cannot wait to see what’s this podcast going to bring to the table!
I learned about Dr. Sinclair on Whitney Cummings’ podcast and immediately after I read your book! Fast forward a few days and I decided to study Molecular Science in University to hopefully research aging one day! I cannot express my admiration for you enough!

[brittneytan]

I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair!

[redpilllense]

This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent!

[Adam-nwvy]

Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now!
The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what.

[drewmoon]

Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate!

[EPFForsyth]

Dr. Sinclair/ and Professor LaPlante you have helped me change my life. I am no longer over weight, no longer have Diabetes/DM2. And I finally feel/ look better. That was a long winded way of saying thank you.

[billgarner]

David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-)

[lotfibouhedjeur]

I'm bursting at the seams with excitement! Dr. Sinclair has an official YouTube channel. I love how assertive he sounds talking about what he knows.

[robertobenedit]

Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules!