Metabolism | Electron Transport Chain: DETAILED | Part 1

Ninja Nerds!

In this lecture Professor Zach Murphy will present on part 1 of this three part series on the Electron Transport Chain (ETC). This will be a detailed discussion on the ETC and the regulatory steps used throughout this process. We hope you enjoy this lecture and be sure to support us below!

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[spiceboi]

4 years ago, and medical students up until today are still surviving with this. We can't thank you enough sir

[reginacrespo]

And the Teacher of the decade award goes to...

[marwadante]

It's so sad that I only got to know u in the night of my exam!! u r amazing! and it's totally frustrating that the viewer's umber is so low, I rlly wish u all the luck from the bottom of my heart cuz u most defenetly deserve it! you are just AMAZING!

[nursesrock]

You know it's hella information when the ninja nerd needs a part 2 and 3...God save us all😂😂😂

[Citrus-sppj]

🎯 Key Takeaways for quick navigation:

00:17 🧬 *The electron transport chain occurs in the inner mitochondrial membrane, specifically in the folded structures called cristae.*
01:40 🔄 *The process starts with glycolysis, converting glucose to pyruvate, and further to acetyl coenzyme A, generating NADH and FADH2 in the Krebs cycle.*
04:53 ⚡ *NADH and FADH2, carrying high-energy electrons, enter the electron transport chain, starting with NADH being oxidized to NAD+.*
06:57 🔄 *Coenzyme Q (Q) receives electrons from NADH and is reduced to QH2, then passes electrons to complex 3 (cytochrome B) in the chain.*
10:57 ⚙️ *Complex 1 (NADH dehydrogenase) and Complex 2 (Succinate dehydrogenase) pass electrons down the chain, with Complex 1 pumping protons into the intermembrane space.*
14:03 🔄 *QH2 passes electrons to cytochrome B, pumping more protons, and then hands off electrons to cytochrome C, continuing the chain.*
18:07 🔗 *Cytochrome C transfers electrons to cytochrome oxidase (Complex 4), leading to the final step where oxygen is involved, forming water.*
22:46 🌬️ *Oxygen is the final electron acceptor in the electron transport chain, forming water when combined with electrons and protons.*
23:40 ⚡ *Energy released during electron transfer at complex 4 is used to pump protons across the inner mitochondrial membrane.*
27:34 🔄 *Protons are pumped out at Complex 1, Complex 3, and Complex 4, contributing to a higher proton concentration in the intermembrane space than the mitochondrial matrix.*
28:30 📊 *Proton concentration gradient across the inner mitochondrial membrane establishes a concentration gradient, a crucial aspect in ATP synthesis.*
28:57 🔄 *NADH produced in glycolysis needs a specific mechanism to enter mitochondria for electron transport, a topic to be covered in the next video.*

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[boatengjoseph]

BORN TO TEACH. PERIOD. Thank you a lot Sir, I nearly quit the understanding of ETC but you've made this topic the easiest one you could ever get. GOD will richly bless you.😍😍🥰

[Kemma-elit]

Literally a life saver . If all lecturers taught like you medschool would be a 100 times easier,
6 years later and you’re still saving the world. Truly not all superheroes wear capes. Some set up a YouTube channel and teach millions of students biochemistry . Thank you ❤❤❤❤

[sanja]

You helped me with Immunology and now Biochemistry, my god what would I be without your videos...I always draw with you and now I can even explain the things myself! You are the best teacher and I will be thankfull forever...telling all my friends you exist <3

[svt_carat]

I'm blown away by your explanation sir. I have urge to show this to my biochem teacher and scream she needs to explain it like this instead of just using smart board in the classroom. I swear you explain so clearly and you enjoy it too. I loved it sir, tha kyiu so much 😭❤🔥

[mohamedtharifj]

I studying this for 3 years just for exam amd forgot it and read it again Now I underdstood at peak level I wish that should have more viewers....

[mlili]

You´re saving my academic life at this point

[collinsonyuka]

The best explanations ever seen on ETC

[anwer]

كل الكلام والوصف قليل بحقك حرفيا اعجز عن وصفك شكرا من القلب 🙏🤍

[NelliButt]

I have to say, it took me some time to realize that the NADH gives one proton to FMN, but i was confused as to why it was FMNH2 and not FMNH since it's getting one proton and 2 electrons from NADH. And in the video he doesn't explain where he got the second proton from. I finally understood that the NADH actually combines with a proton from the matrix which has an abundance of protons. So it's NADH + H+ to FMN = FMNH2.

[victoriaafful]

You are a GPA saver ...u saved me ....6 hours more to write my midsem ...thank you. ..I wish my biochemistry teacher was like u😢😢😢😢

[Mohamed-jvnv]

If you can teach all this stuff so well and so elegantly, and that too almost in no time, I can only imagine how much effort you put in to this! Thank you a lot! ❤️

[evchenbaumi]

as someone with adhd who finds it hard to concentrate in 2 hours lectures, i can't thank you enough for your incredibly well-made videos. you're helping so many future doctors, thank you Sir!

[majinbuu]

the best thing about your teaching is that it seems like 'the things were meant to happen that way', so easy explaination....I tell all of my friends to subscribe ur channel....thank u....Love from India

[janine]

singlehandedly saving my degree by helping me understand Biochemistry

[Gudi]

I've watched countless videos and no one comes close to explaining the ETC as well as you do. Once I get those stacks, I will be sure to donate to your channel.