C-Reactive Protein: What's Optimal? A Comprehensive Review

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Papers referenced in the video:
The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population:

Bioanalytical advances in assays for C-reactive protein:

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians:

High-sensitivity C-reactive protein predicts mortality but not stroke:

Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998:

High sensitive C-reactive protein (hsCRP), cardiovascular events and mortality in the aged: a prospective 9-year follow-up study:

Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study:

Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality:

Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort:

C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study:

High-sensitivity C-reactive protein and cystatin C independently and jointly predict all-cause mortality among the middle-aged and elderly Chinese population:

Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study:

High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in a Japanese Population:

Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein:

Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population:

Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality:

High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study:

An epigenetic biomarker of aging for lifespan and healthspan:

DNA methylation GrimAge strongly predicts lifespan and healthspan:
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I finally finished binge-watching all of your vids, they are amazing props to you Michael!! Hope more good videos are coming soon! Stay safe!

Pawland
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Awesome work, as always. And, nice job on presentation style to go from general to specific like that. You sparked me a few weeks ago to increase my blood testing to every 3 weeks. I'm finding there is no better motivator to stay on track with the diet and exercise than frequent, regular testing. Also, so much easier to hold everything constant and choose just one variable to play with. Chronological age of 50, Levine age of 38, Aging.AI 3.0 age of 32, Aging 2.0 age of 28 (those seems crazy low). CRP (Labcorp 0.0 - 3.0 range) 0.30 mg/L. Keep up the great stuff, Mike!

swenjohnsonify
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Mike - your videos are fantastic - keep them up. I think all your viewers would love a video that is just a video on what you eat/consume in a typical week, and why... You've obviously put a lot of thought into it, and while it is individualized for you, it would give us some insight into your food and nutrition choices and rationales. I've watched your first video on where you touch on this in the "Aging Clocks" video #1, but a video just focused on your weekly nutrition / eating / drinking would be really helpful!

bchik
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Incredibly good. Packed with valuable information. Everyone should know this, but my own doctor probably doesn't even know this in detail.

remcovisser
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Thank you so much for your quick response. Looking forward to watching the video! Thanks for all the work you do – I’ve learned a lot.

bkinstler
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thanks for all the great work compiling and making sense of all these studies.
Also agree with you on the importance of CRP

ccamire
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Nice video, every time you say how low can you go I think of the Cha, Cha, slide song .

Tippytoes
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There seems to be a significant discrepancy between the hs-CRP values of the subjects in this study (n=6, 060) when compared to the subjects in the Kumar et al 2020 study "Glutathione Restoration Improves Hallmarks of Ageing in Older Adults", where the Young Adult (20-30yo) group (n=8) had an average hsCRP of 2.5 ng/ml while in the older (70-80yo) group (n=8) the average was 4.8ng/ml. Maybe the small sample size in Kumar et al is the explanation?

chrismarks
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So the takeaway from all this is to avoid inflammation if you want to extend your lifespan and presumably also your healthspan. What actions can we take to achieve that? I'd nominate eliminating visceral fat and low-level infections. Does fasting reduce inflammation and CRP? ISTR that one theory was that chronic infection with chlamydia pneumoniae was a cause of CVD. So perhaps the CRP level is a proxy for various things that are damaging our health from obesity to infections by bacteria and viruses. Do the studies on centenarians speculate on the reasons for the low CRP in those populations eg robust immune systems, diet, low stress?

stuartm
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Just want to note that apparently quite a few much used medications are reported to lower C-reactive protein. They include statins, common blood thinners, omega-3 lipids, ACE-inhibitors (for high blood pressure). Personally happy to report hs-CRP of 0.3 while in my late sixties (and biological age about 12 years younger by the Levine blood tests). Possibly partly due to some of the above, and a modestly healthy diet, taking some supplements, while at the same time still smoking a pipe every evening when watching some movie.

thaidomain
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On my last few blood tests the lab didn’t provide the exact CRP value but just reported less than 1.0. I would like them to provide the actual values

edwhite
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Mike have you seen any studies on diets or supplements that would help lower High-sensitivity C-Reactive proteins? Or any other therapeutic methods to affect High-sensitivity C-Reactive proteins?

I like your no nonsense, hard numbers, approach in your videos. Thank you for that!!

jonathanmcneill
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How about a video on how to lower Hs-CRP or what works the best?

Max-lsvf
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Awesome video Michael! My two measurements so far are 0.29 and 0.36mg/L, so it looks like I can do even better. I will be sure to look up your videos on how your CRP is correlated with your food to get some ideas to try. You are doing a fantastic job with these videos! Thanks!

neilchristensen
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I only have CRP data. Is there any rule of thumb for the conversion of CRP to hs-CRP?

dirkh
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good deep dive...this makes me feel good about my usual 0.16 hs-crp and 63/70 tg/hdl readings, as i'm in my 70's..🌈

mark-c
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Is there an inverse correlation between c-reactive proteins and sirtuins? Are their treatments that lower CPR?

Earwaxfire
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Great information as always! Have you analyzed your hsCRP as it relates to your food intake over at least a few years? I'd be curious to know what you find, given the amount of data you collect about your food and the fact you don't take many supplements.

gretagroggy
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Such a bad marker to follow for aging and all-cause mortality. High sensitivity and very low specificity. so many things will bring up your hsCRP including vigorous exercise. So many variables. I suppose there are a small sub-set of people in might be useful to follow.

dralexbrothers
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I was less than .2 the last time measured at 49. This is probably due to an anti-inflammatory diet. However, I wonder if there are some negatives from very low inflammation. Don't some of the benefits of exercise come from a hormetic reponse to exercise induced inflammation? Query whether an anti-inflammatory diet would suppress some exercise induced inflammation and thereby reduce the hormetic response?

jackbuaer