Acute inflammation in 2 mins!

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In this video, Dr Matt explains the main steps that cause acute inflammation.
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Acute inflammation response steps:
1. Stimulus: thorn kills immediate cells
2. Mediators (e.g., histamines, cytokines): produced by resident immune cells (macrophages, dendritic, mast: pick up damaged cells) which interact with endothelium of neighbouring blood vessels
3. Vascular: results in endothelial shrinkage and vasodilation for increased blood flow to site of injury, leading to heat and redness. Blood vessels leaky, more fluid goes to tissue, leading to swelling and pain.
4. Cellular: certain immune cells (e.g., neutrophils, macrophages) move out blood vessels and migrate to SOI to phagocytose to clear area of damaged cells and pathogens.
5. Repair/resolution: more blood vessels going to area, bringing repair cells (e.g., fibroblasts) which close off SOI.

disgirldoe_
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There s a space between endothelial cell s.(for diapedeza)

mateitoma
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At the end: is it true that, like, NEW bloodvessels are formed just to reach the affected area?

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