Mechanism of Action for Adenosine

[EagleEye]

Notes: adenosine binds to receptor coupled to inhibitory G-Protein in SA node cells --> activated inhibitory G-protein --> subsequent inactivation of adenylate cyclase --> subsequent inhibition of CAMP and PKA synthesis. Final result = decreased Ca influx into cell and K efflux out of cell --> SA node hyper-polarizes = delayed SA node action potential

[ChristopherGray]

absolutely amazing breakdown, no oversimplifications yet explained in a way that is easy to pick up on and understand. thank you.

[DanielHMC]

I'm assuming this is for med students? I'm very much not a med student, found this video after seeing a random YouTube short about adenosine restarting the heart and wanted to know how it works.

This only made me more clueless 😂

[PeteHob]

Very intricate exclamation all the way down to the cellular level. Now all we need is a little addendum warning the patient how he will feel if God forbid he ever needs this drug.

[EMTB]

Is it not the AV node? Considering that adenosine is used primarily for SVT, would it not make sense to regulate cardiac rhythm at the AV node?

[vineshmanohar]

Thank you! Could u please make a video on how Ranolazine works :)

[musicforaarre]

HOW DO I GET RID OF (NOT BLOCK) ADENOSINE ! I AM CONSTANTLY TIRED, AND I THINK I AM SWIMMING IN IT.
Aarre Peltomaa of Mississauga, Ontario

[Cmartgixer]

Is this occurring on the pre or post synaptic neuron?

[tenisokamuoliukas]

How exactly does reduced PKA synthesis cause a K efflux? Is potassium channel activity decreased by phosphorylation?

[divyajoshi]

Please explain adenosine decrease the k eflux or increases the k eflux?

[rblxmac]

i have to do this in school some time soon :(

[jeffweaver]

Very concise, did not understand a single word