Digoxin - Mechanism of Action

Digoxin: Cardiac glycosides
Heart failure medication

[manshenoy]

This made more sense than my lecturer (bless him) ever did! Thank you!

[richardcoss]

It does not lead to an inactivation of the NA/Ca exchanger but rather the increase in sodium concentration activates it and the sodium is pumped out of the cell in exchange for calcium that leads to increased intracellular calcium and positive inotropic effects.

[anushagopalakrishnan]

Just what I needed, concise and clear. Thank you!

[meghasa]

Wow. Explained in just less than a minute. Thank you so much :)

[bilalbangash]

where was this video guy back when i was in medschool man, it just made so much sense!

[MaryTesse]

The secondary active transport sodium-calcium exchanger will depend on the concentration of sodium outside the cell (extracellular). The more sodium outside, the more it is active in pumping sodium inside the cell in exchange of calcium which is pumped outside the cell. The extracellular sodium concentration is maintained by the primary active transport sodium-potassium ATPase pump. Potassium is pumped inside in exchange for sodium which is pumped outside. Therefore activation of the sodium/calcium exchange (secondary active transport) will indirectly depend on the sodium potassium ATPase pump (primary active transport). The mechanism of Digoxin is that it will inhibit the CARDIAC sodium potassium ATPase pump, decreasing extracellular sodium concentration, leading to the inactivation of the sodium-calcium exchanger. Calcium will not be pumped out therefore increasing the calcium concentration inside the cell. Calcium triggers muscle contraction, hence it will cause the heart to contract. A phenomena we call positive inotropism. Digoxin is an example of a positive inotropic drug.

[barakatadeniji]

Wholesome! Straight to the point with👏👏👌👌

[antonellananini]

Omg i love you 😭😭😭😭 thank you so much!!

[geetanshugandhi]

Its mechanism of action is not that easy...boss!!!

[nana____fox]

thank you 😭😭😭 u got stuck in 1 page of my review because i got so confused and here you are explaining in less than a minute. life saver! pls wish me luck on my up coming licensure examination🥲