I Built 'Smart Yeast' | Journal Club

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After several years, I am finally concluding my PhD. This defense marks the culmination of all of my research, but I wanted to make the information accessible to a more general audience. I studied genetic engineering in non-conventional yeast and utilized CRISPR-Cas9 genome-wide screens as well as PYR1 biosensors.
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[heinzheinz]

Just a suggestion on an interesting compound...
The title of the paper to start with is:
Total Synthesis of Phytotoxic Radulanin A Facilitated by the Photochemical
Ring Expansion of a 2, 2-Dimethylchromene in Flow
Article  in  Organic Letters · June 2022

[colesneed]

i barely have any idea what most of these words mean but i've found myself with an increasing interest in genetic modification stuff!

[PrinceOthemitten]

Do a cocaine yeast next. It’s schedule 2, less illegal than all the other drugs you’ve been talking about

[StevenNess]

i love limonene, very nice and lemony-ish

[StevenNess]

love these papers right from the author! so cool.

[LaboriousCretin]

Nice. Good job and congrats. Keep up the good work. Just makes me wonder on bioluminescent biomarker tagging or flavors and smells put into yeast products. Cheeses, yogurt, alcohol, breads, ect.. genetically engineering smells and tastes. Also simple before complex systems. Yeast that is microbiome engineered for smells and histome trigger range/area and can carry basic health information with the scent. Like DNA placking or mitochondrial health expression, ect.. But thats way more complex. From yeasts, molds and steps. Plants, insects, ect.. bioprinting tattoos ( optogenetics, bioluminescence, pigmentation ( octopus, squid, ect. ). 3D bioprinting and scaffolding and such. Sorry I like some of the technology and what could be done.

Thank you for the video and going over the paper in detail.

[sebleblan]

Hi! How viable is it to crispr in a gene for a ~220aa protein in yeast and produce it industrially? Like not at pharmaceutical quantities but at the level of food production quantities?