8-13 Carbon Dioxide Transport in the Blood (Cambridge AS & A Level Biology, 9700)

When CO2 diffuses into the blood, one of 3 things can happen.

- It dissolves in the plasma
- It enters the Red blood cell and binds with hemoglobin to form carbaminohemoglobin
- It enters the Red blood cell, binds with water (catalyzed by carbonic anhydrase) to form carbonic acid (H2CO3); which splits to becomes H+ and HCO3-. The H+ binds with hemoglobin to form HHb and HCO3- diffuses into the plasma.

HHb is important:
- to prevent the blood pH from becoming too acidic
- to force hemoglobin to release the oxygen its holding onto

when HCO3- diffuses out of the red blood cell, Chloride ions, Cl- move into the cell to rebalance the charges. This is known as a chloride shift.

[AayushmaMoktan-iu]

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[khadijahmohammedarif]

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[musavirfatima]

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[bogscaprisun]

You explained this very well!! Thank you for all the hard work you put into this channel and in all your videos. I was wondering when will you upload Chapter 9? I know that you're very busy and currently uploading 2 chapters at once but just an approximation of when you will upload it would be helpful :))

[Ahmed-tzet]

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[roqayareda]

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[pricilasalema]

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[rayanarfaoui]

why does chloride need to enter the RBC ? hydrogen ions already reacts with hemoglobin means the there is no excess positive charge so if the chloride enter the RBC it should makes it negative charge right?

[qcnnblf]

I have a question, in the biology book it shows that the H+ ions goes out to the plasma along the HCO3- but in this video I saw that the H+ stays in the red blood cells. So does the H+ leave the plasma or does it stay in the red blood cell? Or is it that some H+ leaves the plasma and a few of them stays in red blood cell?

[B.I.b.a.]

i really like your videos and explanation you are really amazing but i would like to ask when will chapter 7 be uploaded and chapter 4 ?

[eileenkarkon]

Why we say chloride shift is to balance ? Hydrogen ions are bind with Hb so they dont have charge!
Can you please explain it

[shaheerairfan]

thank you sooo much sir these are really too helpful
also i have a q that why chloride shift happened bc h positive ions bind to hb to form hemoglobinic acid so is it not balanced it hopw y will clear my concept soon

[ahmediftikhar]

why dose hhb not dissociate again if there is water inside like carbonic acid?

[maheenali]

Sir why hydrogen carbonate moves out of the cell

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