Vitamin D, now conclusive

Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

(Italy)

Various studies, a association between severe vitamin D deficiency and bad COVID-19 outcomes.

Vitamin D plays a crucial role in immune function and inflammation.

Recent data suggest a protective role of vitamin D against bad outcomes

Nutraceutical approach

Promote the immune response and reduce the inflammatory response

Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D

Immune optimisation and immune boosting

Vitamin D maintains pulmonary barrier function

Determines the production of antimicrobial peptides

Enhances neutrophil activity

Shifts the adaptive immune response to a more T helper cell-2 type

Anti-inflammatory effects of vitamin D

Reduces the production of pro-inflammatory cytokines,

such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma

Increases production of anti-inflammatory cytokines,

such as IL-4, IL-5, IL-10

Patients with a low baseline vitamin D, more benefit

Reduce risk of asthma exacerbations

Prevents acute respiratory infections,

and reducing their complications

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials

The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups

(RR = 0.46)

Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity.

Meta-analysis and trial sequential analysis (TSA)

Better explain the strength of association

Protective role of vitamin D supplementation,

and risk of mortality / admission to intensive care units

We searched four databases on 20 September 2022.

Screened the randomized clinical trials (RCTs)

Assessed the risk of bias

(how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached)

The pre-specified outcomes of interest

Mortality and ICU admission

78 bibliographic citations

Five RCTs were suitable for our analysis

Results

Vitamin D administration results in a decreased risk of death, 0.49

Vitamin D administration results in a decreased risk of ICU admission, 0.28

Protective role of vitamin D and ICU admission

The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive.

The studies

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

(Saudi)

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study

(Spain)

Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

(Spain)

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19

(Brazil)

Calcifediol treatment and COVID-19-related outcomes

(Spain)

Medicines & Healthcare products
Regulatory Agency

86% industry funded

[georgespalding]

On your advice I started taking 5, 000 units in mid 2020 and am glad that I did. Came down with COVID two weeks ago and got through it within 7 days like a champ with just a couple of bad days at the beginning. I'm 76 years old and appreciate all the good advice that you have given us over the last three years.

[mikevandesande]

My name is Mike Van de Sande from Canada. Not as proud to be a Canadian citizen as I once was.
I would like to take this opportunity to thank you for your brave and inspiring commentary on this subject. You show what the rest of the worlds experts, doctors, and scientists should be doing. Reporting and working with the facts.and in harmony.
Honesty, open minded, and willing.
I and everyone else owe you a tremendous debt of gratitude.

[MicStowe]

When you literally jump up and give the good doctor a standing ovation. And a virtual hug. Thank you, Sir, you are a precious hero to me and my 98-yr old father.

[rennerbike]

Dr Campbell should be minister of health!!

[KayCeeTX]

It’s okay to be emotional. This IS emotional. It’s devastating for medical professionals who never forgot to First Do No Harm! You are a hero Dr. Campbell. Keep going!!! ❤

[Fuzzy_nutstein]

Your message has gotten through, John. Don't feel like you have wasted your time. I started my entire family on vitamin D because of your videos and I'm sure there are many more out there that had the same response because of the work you've done. Never feel like your efforts were in vain. People have listened.

[michaelkahn]

Tough day, John, but thanks for putting it out there. Your message of vitamin d reached millions people and saved a lot of lives, so you can be happy for that.

[tammybushnell]

We love you, Dr. Campbell. You actually CARE about us and it shows.

[allisonandrews]

Please don’t ever apologize for being angry. I am a former allied medical professional. My own patient experience led me to leave the field, took up second career in health law. Your mild pique and humane moral indignation keeps me sane. Love from the U.S.

[cindyfietzer]

"... a total scandal and a disgrace..."
No truer words have ever been spoken!
Thank you for your efforts!
I teach medical ethics and the last few years have been hard for me with that class!! ( big heavy sigh...)

[madalaine]

Stay strong Dr Campbell..as a nurse myself, it's been a tough few years in a profession we once loved. Witnessing the madness and speaking out against hasn't been easy.

[blondiegirl]

I started vitamin D a few years ago and stopped getting respiratory infections and bad coughs that I was getting before. I had covid twice with no respiratory symptoms. I keep sharing your videos with people and trying to get them to listen. I am an example of proof that it works. Thank you so much for all that you do! You are brilliant and your videos are helping many people!

[s.rogers]

You've been an advocate for D3 from the beginning, thank you for continuing to share your knowledge. I (unvaccinated) contracted COVID Dec '22 and I megadosed D3, along with regular doses of k2, IVM, C and iron. I tested positive on a Friday and was completely healed and tested negative a few days later on Tuesday. No hospital, no lingering effects.

[ArtfullyAdrianne]

Hello John, please don't apologize for being emotional over such a pressing issue. We should all feel this. It is a heavy topic. It is very serious, the health and well being of everyone and the damage that has been done to us all. Thank you for directing this data to us and doing it from your heart. We are blessed to have you here passing on necessary and life saving information. Take care. Remember to do things that bring you joy and treat yourself. These things we are all dealing with are quite a burden. Self care is very important during these hard times.
Grateful for you! 💛

[shananzickefoose]

In am an RN and 2020, you taught me to talk about how important VitD was, even at a cellular level. You taught me how to talk to my staff and clients about receptor cites for VitD. Thank you for being emotional about this topic in today’s post. We need this transparency in the world.

[marycorzette]

Thank you Dr. Campbell for truly having our best interest at heart. We love you for it❤❤❤

[jennytaylor]

P.S. Don't apologise for anything, Dr. John. You're a veritable national treasure at this point, as you're one of the only honest men working in medicine who's willing to stand up and say what you are seeing in real time, in layman's terms, and I take off my hat to you.

[magpie]

Medical nurse here, our consultant, who has written loads of papers on the use of Vit D in the prevention of serious pneumonias in the elderly, recommended that the ward staff take Vit D at the beginning of the pandemic. Many of us followed his advice.

[gracegrace]

Something to help people maintain their health that is strangely absent from the official narrative. Thank you Dr. Campbell !

[lindaedwards]

Thank you so much for explaining all the medical terms, breaking it down and teaching it in a way that most people can understand. What you do is so important and extremely helpful and valuable to people like myself and hundreds of others I am sure . So I just wanted to thank you with all of my heart ❤️.