Know Your Body: Anaphylaxis Explained

We all know what allergies are, and many of us may also be familiar with the term, ‘anaphylaxis’. However, the reason why, and how, anaphylaxis occurs, may be less common knowledge. This video explores the immunoglobulin E-mediated (IgE) pathway, which is commonly activated during anaphylaxis. Subtopics highlighted in this video include what anaphylaxis is, how allergies develop, how anaphylaxis is triggered, and symptoms of anaphylaxis.

This video was made by McMaster University students Jasmine Sodhi, Sara Ukropina, Andy Zhu, and Arina Mojavery in collaboration with the Demystifying Medicine McMaster Program.

Copyright McMaster University 2022

References:

Church, M.K. (2016). Allergy, Histamine and Antihistamines. In: Hattori, Y., Seifert, R. (eds) Histamine and Histamine Receptors in Health and Disease. Handbook of Experimental Pharmacology, vol 241. Springer, Cham. Doi: 10.1007/164_2016_85
Kemp, S.F., Lockey, R.F. (2002). Anaphylaxis: A review of causes and mechanisms. Journal of Allergy and Clinical Immunology, 110(3); 341-348. Doi: 10.1067/mai.2002.126811
Profet, M. (1991). The function of allergy: Immunological defense against toxins. The Quarterly Review of Biology, 66(1); 23-62. Doi: 10.1086/417049
Sampson, H.A. (2003). Anaphylaxis and emergency treatment. Pediatrics, 2003(111); 1601-1608. PMID: 12777599
Waserman, S., Bégin, P., Watson, W. (2018). IgE-mediated food allergy. Allergy, Asthma & Clinical Immunology, 14(55). Doi: 10.1186/s13223-018-0284-3
White, M.V. (1990). The role of histamine in allergic diseases. Journal of Allergy and Clinical Immunology, 86(4); 599-605. Doi: 10.1016/S0091-6749(05)80223-4

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why is this video monetized, the students are not getting paid for this?