Diabetic Ketoacidosis (DKA) Explained Clearly Remastered - DKA Pathophysiology

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. This video is part of the "MedCram Remastered" series: A video we've re-edited & sped up to make learning even more efficient.

This is video 1 of 2 on diabetic ketoacidosis (pathophysiology and signs of diabetic ketoacidosis / DKA):

0:08 DKA stats
0:47 DKA - cellular anatomy
1:00 mitochondria
1:48 beta-oxidation
2:30 insulin function
3:08 pyruvate
3:19 diabetes mellitus type 1
3:26 diabetes mellitus type 2
4:48 ketone bodies (acetone, acetoacetate, b-hydroxybutyrate)
6:09 carboxylic acid
6:23 conjugate base (anion gap acidosis)
7:38 beta-oxidation
8:17 DKA review
8:57 diabetic ketoacidosis - hyperkalemia
9:37 diabetic ketoacidosis - dehydration
9:50 osmotic diuresis
10:10 dehydration
10:27 diabetic ketoacidosis - potassium effects
11:04 diabetic ketoacidosis - Cr elevation / renal failure
11:30 anion gap metabolic acidosis
12:09 measuring ketone bodies (serum ketones, b-hydroxybutyrate)

Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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Produced by Kyle Allred PA-C

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Visit MedCram.com for clarity on over 50 medical topics

Medcram

I like the way u clarify the pathophysiolgy of disease or medical issues, only herein there is one error; human cells have no wall but a membrane wherein receptors are entrenched.

drhanafayyad

In RN school. Love the these videos....when I know the detailed physio behind it... I don't have to memorize.

TheHeyDood

Another very important point is that the ketones are metabolized through Kreb cycle. Every chemical in the Kreb cycle is a form of sugar. When there's not enough insulin, the Kreb cycle shuts down, and beta degradation increases. This leads to rapid increase of ketone bodies. Therefore, the key issue of treating DKA is to restore the Kreb cycle to help burn off ketone bodies and reverse acidosis.

shonezhao

Excellent video sir 🤗but we also want management of DKA 😊

RajKumar-eytg

Thank you for this video. I’m going to NP school and have binge watching your videos for a refresher course.

danamarriee

These are best lecture.
So genius is tha man
I need urinalysis but it need dollars and i left.

mariesa

I'm here because I've been struggling with ketones since I've been diagnosed with Type 1 Diabetes. I've been managing everything that enters my mouth, food to the gram and 2.7QT of water per day, and I have not had 250+ or 70- for 5 days. I'm also on a pump so there should never be a lack of insulin. Yet I'm STILL getting ketones in the higher range (high according to my test strips but not to the point of DKA). No starvation, no dehydration, no lack of insulin, no hyperglycemia, no infection, so why? Could anyone please help me with a POSSIBLE explanation? Thanks!

aporifera