MTHFR polymorphism

This video simplifies the topic of polymorphism and highlights the advantages of Quatrefolic® compared to folic acid for the population affected by this gene mutation.

In fact, methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway, which plays a vital role in methyl group transportation.

A genetic defect (polymorphism) reduces MTHFR enzyme activity, leading to the accumulation of homocysteine. Interestingly, elevated levels of plasma homocysteine have been linked to the pathophysiology of various disorders.

The MTHFR gene has identified two common single nucleotide polymorphisms: C677T and A1298C.

Supplementation with active folate 5-MTHF bypasses the entire folate metabolisation, which is potentially impaired by MTHFR polymorphism, and 5-MTHF is directly absorbed to exert biological activity. Therefore, using 5-MTHF as a food supplement instead of FA is strongly recommended for external supplementation.

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