Cyclins and CDKs in the REGULATION OF THE CELL CYCLE [Retinoblastoma, C-MYC, P53 and CDK inhibitors]

The cell cycle is regulated by an irreversible series of molecular events. In this video, I will be discussing all the key players involved and how they are regulated in detail. We will talk about Cyclins (D, E, A and B) Cyclin dependent kinases (1,2,4 and 6) and the role of other proteins (P53, retinoblastoma protein, C-MYC, and CDK inhibitors) and why they are good drug targets or how they can cause cancer when mutated.

🚩Timestamps🚩

00:00 - Introduction
00:56 - Cyclins and CDKs
01:32 - Growth factors and Cyclin D
02:22 - Cyclin E
03:25 - Cyclin A
04:10 - Cyclin B (MPF)
05:38 - CDK inhibitors
06:33 - P53 and DNA damage
07:37 - C-MYC
08.36 - Summary
09:38 - The end

Thanks for watching! Until next time .. this is the caffeinated medic signing off .... take care!