CELL CYCLE CYCLINS & CYCLIN DEPENDENT KINASES

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Description
  1. Walter Jahn
  2. Cyclin-dependent Kinase (Protein)
  3. Cyclin
  4. Cell Cycle
  5. CANCER
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Комментарии
Автор

Great animation! A slight correction, the activation of a CDK upon Cyclin binding is mediated by phosphorylation of Threonine-160 instead of Threonine-161. For this, I am referring to the book: Lehninger Principles of Biochemistry (6th ed) Page. 486. Please correct me if I am wrong. Thanks

stevanus
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A number of potentially fatal human diseases like cancer involve #cell cycle defects. Cell cycle control is regulated by an evolutionarily conserved family of serine/threonine protein kinases called cyclin-dependent kinases (Cdks) and their regulatory subunits, the cyclins. Critical cell cycle events are both positively and negatively regulated by specific Cdks, whose activities oscillate throughout the cell cycle. Cdk activities are controlled by several different mechanisms, including binding of the positively activating cyclin subunits, inhibition by Cdk inhibitor proteins, phosphorylation by Cdk activating kinases (CAKs) or inhibitory kinases, and dephosphorylation by cell-cycle regulated phosphatases. Creative BioMart

carolinegreen
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thank you for posting
I wander how many times did you say the word cyclin in this video

zainabdookhy
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Does this activation process only work with cyclinB/cdk1 or its the same process for activating any cycline/cdk complex? Thanks!

feruan
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I have a question well why ubiquine target th complex cdk/cyclin for what is for? ....plz i need a answer

nesrineespinoza