Exercise Epigenetics: How muscles respond to a workout | Illumina SciMon Video

We’ve all heard the importance of exercise. Scientists study epigenetic changes in response to exercise. They observe genes upregulated after training was associated with decrease in DNA methylation. They also observe that methylation changes primarily occur in enhancer regions with enrichment for binding motifs for different transcription factors, indicating that training-induced epigenomic reprogramming targets enhancer regions. Sequencing technology today has given us the first epigenomic peeks into how our cells react to exercise. As our cells receive an exercise signal, a cascade of events occurs to respond to the external stimulus. Our epigenome immediately works to selectively turn on and turn off specific genes.

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