The Resilient Brain: Epigenetics, Stress and Lifecourse - Early Life Deprivation - Bruce McEwen

The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor. The healthy brain is resilient and responds to experiences over the lifecourse that produce epigenetic changes. The lifecourse is a “one way stress” in which there is no true reversal but redirection that occurs in response to positive or negative experiences that may be unique to each stage of life. Recorded on 10/11/2019. [Show ID: 35291]

More from: Impact of Early Life Deprivation on Cognition: Implications for the Evolutionary Origins of the Human Mind

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0:00 Introduction
1:40 IMPACT OF EARLY LIFE DEPRIVATION ON COGNITION
2:48 What is Stress?
4:22 Exposome
5:06 Allostatic overload
6:55 Identical twins diverge because of non-shared experiences
8:01 MEDIATORS OF EPIGENETIC INFLUENCES Systemic influences on the brain
9:00 Hippocampus: Target for Stress and Glucocorticoids Gateway to discovering hormone actions on the cognitive and emotional brain
10:45 The Human Hippocampus Under Stress "GPS of the brain": CLINICAL RELEVANCE
11:36 Regular Moderate Exercise Enlarges the Hippocampus
12:48 Metabolic hormones enter and affect the brain Multimorbidity
13:33 Biphasic effects of glucocorticoids and excitatory amino acids
14:55 The Human Brain Under Stress Three Key Brain Areas Under Investigation
15:53 Sex Hormone Action and Sex Differences in the Brain
16:59 Females respond to stress in a different way
18:32 No true "reversal" after stress but rather resilience and recovery
19:06 EARLY LIFE ADVERSITY-LONG-TERM EFFECTS
19:41 Early Life Stress Restricts the possible Epigenetic Responses to Challenges Later in Life
20:42 Developmental Issues for Children

[HeidiHanna]

Thank you so very much for sharing this wonderful lecture from my friend and mentor, the late Dr. Bruce McEwen. I'm grateful to see his amazing work continuing to reach people on your channel. I miss him very much. Keep up the great work!

[sleepsmartsmashstress]

Thank you so very much for sharing this wonderful lecture

[JCResDoc]

*☼ is there a consensus that this is just what we are pretending epigenetics always meant now?*

[bbffmuyy]

What about those brains that strive to thrive, despite abuse and being scapegoated?

[JCResDoc]

☼ 6:30 oh, ok. it just now means that. coolies. wouldnt want to run out of words, so i guess that makes sense.

[nickjamesb]

Why don't we stop beating around the bush and just criminalize shitty parenting? Problem solved