Inflammation and Type 2 Diabetes (2014) By Maja Divjak wehi.tv

Part 1 of two animations about type 2 diabetes. Please note: this video has been updated to improve images and sound. Original video views: 7,968

This animation describes the process of inflammation in type 2 diabetes via a unique structure called the inflammasome. Over time, this process damages the pancreas, eventually leading to decreased insulin secretion and inability to control blood glucose levels. Chronic inflammatory 'lifestyle diseases' such as T2D are rapidly increasing in the western world and will pose a huge health burden in future.

Maja Divjak, 2014

[majadivjak]

Lots of people have been asking what the various inflammatory mediators are that are referred to in this production:
It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...

[theultimatereductionist]

AMAZING job by the team of incredibly hardworking computer modelers & programmers to create these accurate animations!!

[DanielFenandes]

The representation of molecules in your videos always amazes me.

[samuel.hricko]

Simply wonderful, but I'd really appreciate if the commentary used the actual names of the proteins instead of just referring to them just as proteins or "another hormon-like substance"... Not very informative

[oliverjepp]

1) How does excessive glucose in the blood stream damage you if the proper amount of insulin would have told cells to take the glucose into them anyway?
2) What cells take up glucose? All cells? Just certain cells?
3) In this case it was radicals, but how to normal inflammatory proteins get released?
4) What reaction in the body is inflammation supposed to do? Why is it good?

[ProfJennyClark]

Excellent overview of the interaction between insulin production, inflammation, and type II diabetes. Could you provide additional resources to identify the other hormone-like substance released by the beta cells mentioned as well as the other molecules mentioned but not named? Thank you!

[majadivjak]

It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...

[wallyheiderheider]

I think the public needs to eat more fiber, like pumpkin seeds, and sunflower seeds, with every bite of soft food, that we take. It may sound crazy, but more seed in the bloodstream, will reduce the Inflammasomes from forming in the pancreas, and also prevent malaria from spreading in the bloodstream from pregnant mosquitoes biting through the skin with their deadly proboscis!

[kyok]

Great video and I really enjoyed it, but sorry I found one big mistake in the early part of the video: obesity is actually not the cause of the diabetes.

The answer should be insulin resistance due to over-eating of refined carbs is the main culprit.

Here's the why: refined carbs causes constant insulin spike, leads to insulin-resistance, leads to fat cell formation, causes leptin-resistance, hence constant hunger. Thus the eating cycle starts again.

Yes we should treat obesity, but it is not their fault. Refined carbs are the hidden culprit.

[uli]

Fascinating... quality animations!

Does anyone know what the other "hormone like substance" secreted by the beta cells is? I assume it might be some sort of cytokine? and what what would be the evolutionary purpose of secreting it? why should excess glucose cause an immune response?

[anusthing]

This is great, but it would have been very useful to have the names of the proteins involved, and which cell signalling pathways were affected.

[BodyMastermind]

Im confused HELP, is that type 2 or type 1 diabetes, i thought when pancreas can't produce insulin that that is type 1 diabetes?

[ashleytom]

Amazing..Informative...keep doing more and more topics.

[jaym]

Is the inflammation originating from overfed fat cells in the gut?

[johnx]

Great graphics, great commentary why the crappy sound-effects? Completely destroyed the content for me.

[racheid]

awesome animation, but the sound effects are super distracting and really corny.

[angelabrisbane]

Very insightful video and very logically presented, but what is the name of the small signalling protein (the key protein involved in inflammation in the body), converted by the newly active proteins made by the inflammasome? And why can't you include the actual names of these proteins?

[pallavibarhate]

Mesmerizing video with complex structures made so simple to understand!

[jennataylor-williams]

Can anyone tell me how I can find a source for this information? Its the exact information that I need but I cant reference a YouTube video. Thanks in advance

[Chareidos]

Could this mechanism be actually the result of an evolutionary balancing process, preventing Beta-Cells to overpopulate and/or oversupplying the system with insulin, and is now our doom, because clycose levels never had been that high before it has become this way due to our modern diet?
My Question is, if that could be some kind of a secondary function for the immunesystem to react on certain eventualities. Does something like a hyperactive Insulin-System exists, which would be prevented by population-control-mechanism? Just wondering here.