Combining Target Based and Phenotypic Discovery Assays for Drug Repurposing

Drug repurposing can be a cost-effective means of addressing unmet medical needs. For drugs such as kinase inhibitors that can have multiple targets, a strategy that combines both target-based and phenotypic screening can be highly efficient at identifying optimal repurposing opportunities. Here we will show an example of how phenotypic profiling identified approved kinase inhibitors as having the potential to be repurposed as anti-fibrotic therapeutics.