Combining Target Based and Phenotypic Discovery Assays for Drug Repurposing

Drug repurposing is a relatively low risk and cost-effective means of develop therapies to address unmet medical needs. For drugs such as kinase inhibitors that can have multiple targets, a strategy that combines both target-based and phenotypic screening can be highly efficient at identifying optimal repurposing opportunities. Here we will show an example of how phenotypic profiling identified the repurposing potential of approved kinase inhibitors as anti-fibrotic therapeutics.