NMN vs. NR: What’s better? And is TMG necessary?

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[kevinklein]

Hey Chris, I was wondering if you also can take Msm (methylsulfonylmethane) instead tmg for providing methyl groups? I only hear about tmg every time...

[SWilkin]

What about sublingual NMN? I have absorption issues all around so I use sublinguals and patches a lot. I had a weird thing happen when I started using injectible insulin where it all became active at once when I took a sublingual NMN. Turns out you need B3 to activate that form of insulin and I was deficit.

[izzerstennisscorekeeper]

Thanks for vid. For past week I have taken NR sublingual. Mornings, I dissolve 300 mg in shot glass with a bit of water and pour under tongue, holding 20 minutes. I like the effect so far. Biggest NR benefits over last 4 months for me have been better flexibility, skin, mood. Hope I'm not demethylating!

[tomlwallace]

Hi Chris, . Instead of TMG any thoughts on going with food and just eating a beet every day? For reference I'm taking 300 mg NR. Experimented earlier with 500 mg of NMN. Prefer NR for one of the reasons you brought up, more human studies.

[maggie]

I like your idea of taking the doses with each meal. I struggle with a high dose in am. Trying this today!!

[crockettstheme]

There is some discussion online among people who take NMN or NR regarding whether or not to refrigerate it. And some have asked if it is already spoiled by the time they get it at the store. Any thoughts?

[tevele]

David Sinclair said that he did the experiment (NMN) on mice with small doses and there is no effect.

[ericklein]

I believe Sinclair says NR needs to be converted into NMN in order to enter the cell via NMN receptor. (Found my fitness podcast).

[MarmaladeINFP]

There have been some more research this past year on NAD+ boosters, specifically human studies on NMN. Also, liposomal NMN has come on the market, although one could always make it at home. It seems to me, since the liposomal form doesn't degrade and crosses the cell membrane intact, there would be no need for supplementing methyl groups.

[jonhylow]

If I intend to take 100 mg NAD + per day, how much TMG powder should I add to my diet ? or should I consume the raw version of NAD instead ?

[factchecker]

Any comment on the new study of egcg and fatty liver?

[mrsbj]

What about Nuchido claims to have bigger effect than NR??

[jenniferlabrum]

Can you take NR at night with TMG? Or when is the best time to take it? I watched the video about diabetes and taking NR where you talk about carbs and fats being used differently

[davidford]

Can I take both Nicotinic acid and nr at the same time?

[precisionmedicine]

I love that you put $300 down that NR wouldn't work for hepatic steatosis (which it didn't).

[gatersaw]

TLDR: contradicting contradictions

Empiricism used to mean something

Try them both. See what works for you.

[Kanonka]

What kinda nmn are you taking, specific brand ?

[mattca]

N=1 but I've noticed a steep difference in mental agility and sleep pattern after being off 300mg of NR (ran out of my Thorne Resveracel) for 2 - 3 weeks, once.

By the way, I've been running 600mg of TMG for 300mg of NR, is there any problem with that? Just curious :)..

I'll try splitting the intake between meals and see how to goes.

Thanks for the content!

[moonoom]

So when you do NAD Iv, it's broken down to nmn and in the cell it becomes NAD again?

[peterkalksma]

This is 4 year old. Have you changed your mind at all on NMN, NR TMG?