Inflammation, Think Again - Full Documentary

Inflammation is blamed for causing everything from obesity, to heart disease, high blood pressure, arthritis, asthma, ulcers, oral diseases, celiac, gut issues such as IBS, Crohn's, and ulcerative colitis, autoimmune diseases in general, and so much more.

In The Principia (1687), Isaac Newton’s seminal work on the mathematical exploration of Nature, he states that "To any action there is always an opposite and equal reaction; in other words, the actions of two bodies upon each other are always equal and always opposite in direction."

Inflammation is the body’s chief compensatory response to chemical stress.

The main macro process of opposing forces within your body is most easily understood as regeneration versus degeneration, and the oppositional nature between the two is almost entirely influenced by environmental factors: the inputs that either allow for the cells to coherently regenerate, or to dissonantly degenerate.

Inflammation, with the right element of control, is a natural part of regeneration, a process known as hormesis. Hormesis is the impetus for adaptation, and the subsequent development of growth and increased strength within the system. Hormetic stress is especially important in physical training, mitochondrial adaptations, and the maintenance of homeostasis (which is itself a demonstration of the body’s innate drive to balance).

On the other hand, inflammation when uncontrolled, drives degeneration. Cellular dissonance caused by inflammatory reactions manifests in systemic dysfunction in tissues, organs, and organ systems.

As the body seeks homeostasis, the continual environmental input of inflammatory “blockers” compels it to find resources from within (since they’re not being provided externally), in order to balance this degeneration, pulling micronutrients from important storage areas with inherently limited supplies.

In 2012, the pioneering physiologist Dr. Raymond Peat, PhD from the University of Oregon, wrote about an illuminating observation regarding the nature of the effect of inflammation on aging (degeneration) in an organism by investigating the patterns seen in the brain development of different birds, relative to their gestational environment.

The chicken egg, when incubated with heat from the mother hen, is a self-contained environment with all of the resources necessary for the development of a healthy baby chick, including glucose and nutrient-dense yolk. Brain growth stops when the chick embryo has consumed all of the available glucose within the egg, and needs to switch to consuming the fat of the yolk.

Chickens are known as precocial birds, meaning the chicks are completely developed when hatched, and therefore do not require further attention or care from the parent to survive into adulthood.

They concluded that “brain weight and DNA were found to be significantly correlated with blood glucose level” and that “early brain growth might be manipulated in both directions (inhibition or stimulation) by addition of proper nutrients during the sensitive period of neuronal proliferation.”

The positive influence of gestational glucose on brain development of the embryo has long been observed in many species, including humans. Results highlight the reality that glucose availability leads to larger brain sizes and increased neuron count in the newborn.

Over time, inflammation changes the way your body can operate, namely how effectively it can regenerate, or heal itself. This is due to internal shifts in resource availability, like nutrients, that the body needs for regenerative processes.

You’ll notice that, in children and teenagers, the body can heal itself quite quickly after injury, due to a higher regenerative capacity. Over time, as the body is exposed to an increasing amount of inflammatory environmental “blockers,” it has a decreasingly effective ability to recover.

The build up of inflammation inside your body is responsible for this, and you experience an increase in degeneration as you age, and eventually lose the regenerative ability entirely, resulting in death.

The inflammation response inside the body is characterized mainly by triggering the release of compounds known as inflammatory cytokines, which are catabolic, such as the interleukins IL-1β, TNFα, IL-6, IL-15, IL-17, and IL-18.

However, to highlight the opposing nature of regenerative and degenerative inflammation, it’s important to understand that the body also has a host of anti-inflammatory interleukins such as IL-4, IL-10, and IL-13, which stimulate anabolic processes to restore order.

[lieblermd]

Great episode 👏
The quality of your videos has been getting better and better.
And it's good that you're shedding light on these kinds of subjects.
Inflammation has its place in muscle growth and wound healing,
but chronic inflammation signals a systemic issue.

[angelicaborges]

Incredible video! I am a registered nurse, have been following doctors orders and medicating patients over 13 years...as I offer these medications I think to myself how counterproductive they may be. After going through a hysterectomy for cancer in citu of the cervix, I've encountered a cascade of hormonal imbalances. Pcos, possible microprolactinoma, high estrogen, low progesterone and recently diagnosed with thyroiditis. I'm 34! Feels like my health has deteriorated very quickly these last 4 years post hysterectomy. I've had no luck with my doctors and the medications prescribed are still sitting in the pharmacy because they don't feel like the right answer. Finding your channel has been godsend. I am literally studying your videos and taking a little bit from all of them in attempt to find the answers to the root cause to the issues I am facing. Your doing incredible work and changing lives. Wanted to thank you for dedicating yourself so passionately.

[CadanPalfreeman]

Be like an Altricial Bird, Keep that metabolism high and have good amounts of glucose! Man i wish my mum did not feed me poly unsaturated fatty acids as a kid and in the womb! Also keep your ratio of CO2 to oxygen highest as possible like an xenopus! Make your diet richer in Glycine to inhibit the cytokine reaction of ageing and don't over eat muscle meats which can give your body an amino acid unbalance because of the high levels of methionine and instead eat more organ tissues etc. This will increase glutathione production which will benefit your body's ability to regulate inflammation. Turmeric/Cur cumin/Frankincense instead of Chemical Pills for Inflammation. Eat Bromelein from pineapples! Poly phenols From Olive Leaf Extract too! Vitamin B3 from Chicken! Vitamin B6 from Bananas. All of this will help regulate your inflammation. Great video i hope i did not make any mistakes in this!

[jeancarlohim]

This is the type of episode that I have to watch 5 times in order to internalize information.

Great stuff, keep it up.

[ncgunner]

I've never seen inflammation broken down this way! Very informative video! Thank you

[ChristianChase]

Shoutout to Ray Peat! It’s easy to see how heavily influenced some of your content is from his work. The information you’re bringing to light about thyroid, metabolism, CO2, serotonin, glucose and more is extremely important. Your understanding of energy metabolism is on point. I would love to see more from you about other aspects of life and health that couple with thermo diet that are outside of the food paradigm such as the absolutely necessity of full-spectrum sunlight, UV light, red light, infrared light. Also I’m not sure if you’ve talked about vitamin B1 (see the work of Derrick Lonsdale) but it’s a carbonic anhydrase inhibitor and can boost CO2 levels. Most people don’t know this about vitamin B1. Absolutely essential for glucose metabolism.

[c.m.]

It has gotten so bad that I just found out I have MCAS (Mast Cell Activation Syndrome, a histamine intolerance) and was given Cromolyn, which has such intense nasty side effects within 30 minutes I felt like I was dying. I looked up the items as you suggested them and was placing orders with Amazon as I read the reviews! What people were saying in the reviews was really impressive and confirmed what you were saying.

This is priceless info, and I thank you so much.

[adamlittle]

Every time a video pops up, the editing just keeps getting better. You're absolutely dominating it dawg. Just inspires me to keep elevating the status of my health and bringing it to the next level. Time to crush a THOR workout now ;)

[ajanta]

Man... how can one determine what they need to consume in a day to be in tip top shape? there are so many variables... supplements (finding a non bs one at that), eating the right food, getting the right amount of exercise. This is tough. I feel like i need to eat a salad of supplements.

[samshms]

Great episode Chris, as usual.
Conclusion, do you have the supplement with all the compounds you mentioned in it, a least glycine, curcuim, and the pineapple extract??
Thanks a lot for your time.
Awaiting your episode about fulvic acid

[gilbertsix]

Fantastic. Well made, great content, high production value.

[handsomecriminal]

This video is insanely good and so informative, it’s insane.

[-Ry-Guy]

Dude! I have been desp inro the health education for 2 years just like you started when you had to fix yourself. Keep up the good it is inanse how fhe answers are all there, you just have to dig for them because most doctors don’t know 1/100th of this type of info! Keep being awesome!

[joshuaniemann]

Kick ass information man. Loving the think again series!

[karen]

That was AWESOME information..THANK YOU😎

[keralee]

I witnessed a Macaw learn reiki just by watching me do it once. And then it healed its owner of a stubbed toe a week later..by putting its beak over the damaged digit..and periodically looking up at her and saying "no bite." To reassure her that he was not intending to bite her toe. When the pain was gone he waddled back to his perch and emanated smugness. Dont ask me how--but he did.
I have completely revised my opinions of bird intelligence.

[HVACleadgeneration]

So. Is there just. A quick lists for what we need

[tym]

The production value and information in this was superb 👏 👌
What do we do and or take to cover our bases?

[ezlymartinez]

Thank you for sharing your knowledge it answered alot of my questions that I've been feeling trying to figure out why I feel certain ways your onto something good I'ma try umzo

[TopGeezers]

Chris what do you say about people who recommend to not combine carbs and fats in the same meal because of their claim that we aren’t able to digest both together so one will be stored as fat?