Protein restriction improves glucose and lipid homeostasis | J. Mitchell | ÄGHE Fasting Congress

► Protein restriction improves glucose and lipid homeostasis independent of total calorie intake ✔

During the 18th International Congress of the German Medical Association for Fasting and Nutrition (ÄGHE), James Mitchell gave an interesting lecture about: “Protein restriction improves glucose and lipid homeostasis independent of total calorie intake”.

𝗔𝗯𝗼𝘂𝘁 𝗝𝗮𝗺𝗲𝘀 𝗠𝗶𝘁𝗰𝗵𝗲𝗹𝗹 𝗣𝗵𝗗
- Associate Professor of Genetics and Complex Diseases
- Harvard T.H. Chan School of Public Health, Boston
This video of Professor James Mitchell has a great scientific as well as emotional value since this outstanding scientist and dear friend passed away tragically in an accident on November 18, 2020. We miss him and feel very close to his wife, sons and colleagues.

𝗔𝗯𝗼𝘂𝘁 𝘁𝗵𝗲 𝗰𝗼𝗻𝗴𝗿𝗲𝘀𝘀 𝗼𝗳 𝘁𝗵𝗲 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗔𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗙𝗮𝘀𝘁𝗶𝗻𝗴 𝗮𝗻𝗱 𝗡𝘂𝘁𝗿𝗶𝘁𝗶𝗼𝗻 (Ä𝗚𝗛𝗘)
The congress took place June 2019 in Überlingen, Lake Constance. The ÄGHE congress is organised in cooperation with Buchinger Wilhelmi clinics and the Maria Buchinger Foundation.
Together with internationally renowned scientists such as Mark Mattson, Andreas Michalsen, Frank Madeo, James Mitchell, Françoise Wilhelmi de Toledo, Jean-Jacques Trochon, and other fasting experts the following topics were discussed:
- Indications and contraindications for fasting
- Biological and genetic mechanisms associated with fasting
- Results of the latest scientific studies on fasting in humans
- The spiritual dimension of fasting

𝗖𝗼𝗻𝘁𝗲𝗻𝘁 𝗢𝘃𝗲𝗿𝘃𝗶𝗲𝘄:
0:00 Intro
1:38 Calorie restriction for studying agening in animals
4:28 Study in human beings
5:06 Nutritional basis of calorie restriction
6:45 Protein restriction without calorie restriction
7:05 Protein replacement
8:20 Benefits: Stress resistance
10:20 Changes in metabolism
11:44 Summary
12:38 Circulating triglycerides
23:23 Translation to humans
27:50 Take aways

𝗪𝗮𝘁𝗰𝗵 𝗺𝗼𝗿𝗲 𝗕𝘂𝗰𝗵𝗶𝗻𝗴𝗲𝗿 𝗪𝗶𝗹𝗵𝗲𝗹𝗺𝗶 𝗳𝗮𝘀𝘁𝗶𝗻𝗴 𝘃𝗶𝗱𝗲𝗼𝘀 𝗵𝗲𝗿𝗲:

𝗗𝗼 𝘆𝗼𝘂 𝗵𝗮𝘃𝗲 𝗮𝗻𝘆 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀?
Feel free to post them in the comment section bellow. We might answer them in one of our upcoming videos.

📊 𝗙𝘂𝗿𝘁𝗵𝗲𝗿 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝘁𝗵𝗲 𝗕𝘂𝗰𝗵𝗶𝗻𝗴𝗲𝗿 𝗪𝗶𝗹𝗵𝗲𝗹𝗺𝗶 𝗖𝗹𝗶𝗻𝗶𝗰:

✅ 𝗙𝗼𝗹𝗹𝗼𝘄 #𝗕𝘂𝗰𝗵𝗶𝗻𝗴𝗲𝗿𝗪𝗶𝗹𝗵𝗲𝗹𝗺𝗶:

[daveoatway]

Interesting presentation. WHat is the effect of protein restriction on sarcopenia in old people (I am 77)?

[allencrider]

I've had good results (lower blood pressure) from Longo's Fasting Mimicking Diet a month ago, and right now I'm trying five days of Kempner's Rice Diet, keeping protein below 20 grams per day. Summertime is a good time for ad libitum fruit eating!

[galaxymetta]

Any anti aging expert will tell you proteins activate mtor which is great for growth but it switches off sirtuins, the longevity genes. You can't have it both ways. That is why carnivorous society like eskimos, Masai, Mongols etc have lower lifespan. Even carnivorous animals have less than half the lifespan of herbivores.

[cherieb]

Thank you for sharing this fascinating presentation. I’m saddened to learn that his life was cut short. His contributions to longevity research will live on.

[johnbemery]

Human milk is about 5% protein, one of the lowest percentages among mammals. If we only need 5% when we are doubling our muscle mass so rapidly, we probably don't need much more when we are full grown.
The body can store excess dietary fats and carbohydrates, but has no mechanism for storing excess protein, it simply treats the excess as a waste product. Fats and carbohydrates are sources of energy, while proteins are used to build and repair tissue, they serve a different function. Fats and carbohydrates are used up, protein is recycled. Nature is telling us we don't need much protein.

[jayjam]

A superb lecture and hypothesis. Grateful to this channel for enabling and sharing.

[omadoutlaw]

We can't really trust animal studies, but we can take it under advisory. Fasting is better than calorie restriction.

[betzib]

Are there any other papers of his published before his untimely death? Does anyone know? This is so adstonishing.

[StarOnTheWater]

I've recently done some research into the umami taste which is basically our sensual perception of glutamine, signalling high protein or fermented foods.
If the fasted state under a LP diet is controlled by the brain this is likely to be a factor.
Interesting in that context: even a diet very low in protein can exhibit an intensive umami taste though seasoning (soy sauce, fish sauce, mushrooms...). Would this change the signaling? There are studies suggesting that glutamine and leucine intake have a very specific effect on the mTOR pathways.

[zohrehshayan]

thank you for providing great information. However I am now confused. If we increase the carb as opposed to protein does t that increase the insuline which causes insulin resistance? Also after fasting do we not need protein to replace the loss of protein during autophagy?

[Starchaser]

I prefer to say " Adequate Protein " rather than " Low Protein ".

[KTPurdy]

Except I've read from multiple sources that plant based protein have lower amounts of BCAA. How do we reconcile this?

[firepowerjohan]

The number one metric for longevity is VO2 max. I wonder what research say about protein restriction in ppl that exercise cardio regularly and maintains VO2 max.

Furthermore, would not the ideal combination be to do intermittent fasting and exercise together, which means u can tolerate more protein for repairs and maintaining muscle mass and still give body chance to repair.

Exercise also induce autophagy, but u also need more protein.

IMO, restricting proteins increase lifespan only if u were overeating protein before, which is very easy if you live a passive live.

[enough]

How do we get the amino acids we need or do we eat a low calorie diet of mostly animal protein

[kennedybutiko]

This is not new, the 3 Hebrews boys in the bible asked the king's people to give them only grains and vegetables after months they were compared with those who are on the fatty proteins at the king's table and they were more healthier.

[lauraatkocius]

Not enough information about how fat plays into the equations.

[Southwesterns]

Why not include the data on and and glycine?

[elizabethnadeau]

James Mitchell is a colleague of Walter Whillett of the Harvard T. H. Chan School of Public Health. He is a long standing nutritionist who has staked his entire 30 year career on the premise that fat and not carbs are deleterious to human health. Now that fat is proven to no longer be the culprit, they are looking to protein to blame. Don't believe them. The problem is with the carbs. Fasting is good, good quality protein and saturated fat are good, and over-consumption of ultra processed carbs and oils will bring an early and painful death.

[lucaslouzada]

The old short-term/long-term fallacy, where weight, lipidic profile, blood glucose and triglycerides are taken as a long-term longevity index, whereas changes in short-term would be somehow indicative of a long-term tendency - a hypothesis that wasn’t even animal tested - which is finally “explaned” through an observational study that doesn’t account for calories. Science progresses when objective hypothesis are posed, until general assertions become inevitable and necessary, as much as rhetoric is the clear winner when you prefer - for some subjective reason - to assume a number of absolutely crucial hypothesis are magically proven because they don’t seem to matter much…

[misterb.s.]

This is mind-blowing to me, but it kind of makes sense. Protein is the most energy-intensive macronutrient to digest and use for energy. For losing weight, this is great because protein is very filling, but the overall caloric impact is lower because of the thermic effect.

As an athlete, I don't think I can reduce my protein intake very much, I need to build muscle and retain it while in a calorie deficit for weight cuts. But as I get older I may have to implement this approach for longevity and undergoing surgery.