Guillain-Barre syndrome

Pathophysiology:
Immune mediated demyelinating polyneuropathy (molecular mimicry)
Preceding GI (Campylobacter) or respiratory infection

Signs / symptoms:
Paresthesia, neuropathic pain
Symmetric, ascending weakness
Decreased/absent DTRs
Autonomic dysfunction (arrhythmia, ileus)
Respiratory compromise

Diagnosis:
Clinical
Supportive findings:
CSF: high protein, normal WBCs
Abnormal EMG and nerve conduction
MRI: normal or enhancement of anterior nerve roots / cauda equina

Treatment / management:
Monitoring of autonomic and respiratory function: tidal volume, neg inspiratory force
IVIG or plasmapheresis (if nonambulatory and within 4 weeks of onset)