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Guillain-Barre syndrome

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Pathophysiology:
Immune mediated demyelinating polyneuropathy (molecular mimicry)
Preceding GI (Campylobacter) or respiratory infection
Signs / symptoms:
Paresthesia, neuropathic pain
Symmetric, ascending weakness
Decreased/absent DTRs
Autonomic dysfunction (arrhythmia, ileus)
Respiratory compromise
Diagnosis:
Clinical
Supportive findings:
CSF: high protein, normal WBCs
Abnormal EMG and nerve conduction
MRI: normal or enhancement of anterior nerve roots / cauda equina
Treatment / management:
Monitoring of autonomic and respiratory function: tidal volume, neg inspiratory force
IVIG or plasmapheresis (if nonambulatory and within 4 weeks of onset)
Immune mediated demyelinating polyneuropathy (molecular mimicry)
Preceding GI (Campylobacter) or respiratory infection
Signs / symptoms:
Paresthesia, neuropathic pain
Symmetric, ascending weakness
Decreased/absent DTRs
Autonomic dysfunction (arrhythmia, ileus)
Respiratory compromise
Diagnosis:
Clinical
Supportive findings:
CSF: high protein, normal WBCs
Abnormal EMG and nerve conduction
MRI: normal or enhancement of anterior nerve roots / cauda equina
Treatment / management:
Monitoring of autonomic and respiratory function: tidal volume, neg inspiratory force
IVIG or plasmapheresis (if nonambulatory and within 4 weeks of onset)